ASSESSMENT OF THE TABLETING CHARACTERISTICS OF A NOVEL SORBITOL AND CALCIUM DIPHOSPHATE COMPOSITES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: To improve the tableting properties of sorbitol (SOR) via particle engineering through agglomeration with anhydrous calcium diphosphate (ACD) employing a house-made agglomerator.Methods: A novel SOR: ACD composites were produced by agglomeration at the 95:5; 80:20, 50:50, 20:80 and 6:94 SOR to ACD. The resulting tableting properties such as densification, compressibility, compactibility, ejection force, elastic recovery, sensitivity to lubricants, compression speed and disintegration time were then evaluated.Results: The new agglomerated excipient had better flow, compressibility and compactibility than the physical mixture of SOR and ACD being the 95:5 SOR: ACD ratio the composite that exhibited the best tableting properties.Conclusion: This novel excipient has a potential use as a pharmaceutical aid for direct compression applications.Â
Authors and Affiliations
Edward Echeverri, John Rojas, Marcel Yepes
Keywords
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