ANTIOXIDANT AND FREE RADICAL SCAVENGING CAPACITY OF RED SEAWEED HYPNEA VALENTIAE FROM RAMESHWARAM COAST TAMIL NADU, INDIA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objectives: In this study, In-vitro antioxidant and free radical scavenging activity of Hypnea valentiae was evaluated in a series of in vitro assays. Antioxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress.Methods: The evaluation of antioxidant properties was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2’-azinobis 3ethylbenzthiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), nitric oxide scavenging assay (NO), reducing power, superoxide, hydroxyl radical scavenging and hydrogen peroxide radical assay, the metal chelating activity as well as phosphomolypdenum assay.Results: Among the tested red algae, the maximum antioxidant activity was recorded in the methanol extract of Hypnea valentiae. Whereas methanol crude extract of red algae and diatom showed good antioxidant potential.Conclusions: The findings of the present study suggest that all seaweed extracts could be a potential source of natural antioxidant that could have great importance as therapeutic agents.Â
Authors and Affiliations
Revathi D. , Baskaran K. , Subashini R.
EMULSIFYING PROPERTIES OF AFZELIA GUM IN LIQUID PARAFFIN EMULSION
Objective: Afzelia africana gum has been shown to possess surface activity. It is a good alternative to sodium carboxy methylcellulose in terms of suspending properties. This work was aimed at evaluating the emulsifying...
DETERMINATION OF IRBESARTAN AND SINENSETIN SIMULTANEOUSLY BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY AND THEIR APPLICATION TO DRUG INTERACTION STUDY IN RAT PLASMA
Objective: To determine and validate of irbesartan and sinensetin simultaneously by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and application of this method to study a pharmacokinetic interaction of irbes...
IN VIVO EVALUATION OF BUDESONIDE MICROSPHERES FOR COLON SPECIFIC DRUG DELIVERY
Objective: The aim of the present study was to evaluate the in vivo behaviour of budesonide microspheres for colon targeted delivery.Methods: In vivo therapeutic effect was evaluated using trinitrobenzene sulfonic acid (...
INFLUENCE OF PERMANGANATE INDEX IN THE PARAMETERS AS TOTAL PHENOL CONTENT AND TOTAL ANTIOXIDANT ACTIVITY OF EXTRACTS OF CAMELLIA SINENSIS
Objective: This study estimated the Permangante Index (IKMnO4) and evaluated its correlation with parameters as total phenols (FT) and total antioxidant activity (TAA) of commercial teas of Camellia sinensis, fermented,...
INHALED TASTE MASKED SPRAY DRIED KETOTIFEN MICROPARTICLES: FORMULATION, CHARACTERIZATION AND IN VITRO PULMONARY DEPOSITION
Objective: Preparation and characterization of inhalable taste masked microparticles (MPs) loaded with the anti-asthmatic bitter drug, ketotifen (KT).Methods: MPs were prepared by a spray-drying technique. The effects of...