INHALED TASTE MASKED SPRAY DRIED KETOTIFEN MICROPARTICLES: FORMULATION, CHARACTERIZATION AND IN VITRO PULMONARY DEPOSITION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 6
Abstract
Objective: Preparation and characterization of inhalable taste masked microparticles (MPs) loaded with the anti-asthmatic bitter drug, ketotifen (KT).Methods: MPs were prepared by a spray-drying technique. The effects of addition of different excipients namely: mannitol, leucine and hyaluronic acid (HA) on the physicochemical properties of KT spray dried powders were determined. Powder taste was evaluated on volunteers. DSC and x-ray diffraction were done to investigate thermal and crystallographic properties of the powders. The surface morphology and shape of KT-loaded hyaluronic acid MPs were examined using scanning electron microscope, in vitro pulmonary deposition and inhalation indices were determined using a twin stage glass impinger (TSI).Results: Leucine improved the powder flow properties. Mannitol, at all tested ratios, produced brownish discoloration in spray dried powders (SDP) upon storage even in dessicator. At a drug to HA ratio of 1:2, the bitter taste of KT had significantly improved besides obtaining a high respirable particle fraction. This selected ratio showed good physicochemical stability for up to 9 mo.Conclusion: The developed KT spray dried particles may offer a good platform for the targeted pulmonary delivery of the drug overcoming the major biological barriers.Keywords: Ketotifen, Microparticles, Pulmonary delivery, Hyaluronic acid, Taste masking, Spray drying
Authors and Affiliations
Dalia M. Elbehairy, Rihab Osman, Omaima Sammour
Keywords
Related Articles
- EP ID EP576329
- DOI -
- Views 46
- Downloads 0
ENHANCED PRODUCTION OF PSORALEN THROUGH ELICITORS TREATMENT IN ADVENTITIOUS ROOT CULTURE OF PSORALEA CORYLIFOLIA L.
Objective: The present study aimed to determine the effect of two elicitors namely Methyl Jasmonate (MeJ) and Salicylic acid (SA) on adventitious root production of Psoralea corylifolia L. as the elicitors and at differe...
TOXIC AND IMMUNOTOXIC EVALUATION OF KETAMINE AND/OR ETHANOL IN RATS DURING 28 DAYS
Objective: Studies have shown that ketamine (K) and ethanol (E) have immunomodulatory activity; however, few studies were performed with concomitant treatments. Thus, we evaluated the toxic and immunotoxic effects of thi...
FECUNDITY STUDIES OF ANDROGRAPHIS PANICULATA ON DROSOPHILA MELANOGASTER
Objective: Andrographis paniculata is widely used in Asia for various medicinal purposes. The plant has a major bioactive chemical constituent Andrographolide, which exhibits various essential pharmacological properties....
ANTIDIABETIC ACTIVITY OF CLERODENDRUM PHILIPPINUM SCHAUER LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Objective: The present study has been undertaken to evaluate the antidiabetic activity of Clerodendrum philippinum Schauer leaves.Methods: The fresh leaves were collected from Kuruan village of Jajpur district in the sta...
THE STABILITY OF GENERIC MEROPENEM IN TROPICAL COUNTRIES
Objective: To evaluate the stability of two brands of generic meropenem at high ambient temperatures and various concentrations in solution.Methods: Generic meropenem brand A and brand B vials were used to prepare 10 mg/...