Antioxidant Potential of Some Under-Utilized Fruits
Journal Title: Indo Global Journal of Pharmaceutical Sciences - Year 2011, Vol 1, Issue 1
Abstract
To identify their potential sources extracts of some fruits and their different parts were studied for total phenolic contents (TPC), antioxidant (AOA) and free radical scavenging activities (FRSA). Phenols have profound importance due to their biological and free radical scavenging activities. The amount of TPC varied from 10.5 to 343.2 mg/g and AOA from 20.3 to 96.7%. Fruits of Caesalpinia mexicana, Acacia auriculiformis, fruit pericarp fibres of Cocus nucifera, and fruits of Emblica officinalis were found to have high TPC (73.1-343.2 mg/g) and high AOA (68.5-96.7%). Promising fruits were studied for their FRSA and reducing power (RP) measured by DPPH assay where the fruits of Caesalpinia mexicana, fruit pericarp fibres of Cocus nucifera, fruits of Emblica officinalis showed very low IC50 ranging from 0.009 to 0.016 mg/ml, EC50 from 0.39 to 0.70 mg/mg DPPH and reasonably high values (142.1- 256.3) of anti radical power (ARP), indicating their strong FRSA and reducing power (RP) as evident by their low ASE/ml values (0.42- 1.08). They also showed better inhibition of lipid peroxidation measured by using ferric thiocyanate assay and by using egg yolk compared to reference standard, quercetin. The ferrous and ferric ion chelating capacity of the promising fruits and their underutilized parts in terms of IC50 varied from 0.12 (Emblica officinalis, fruits) to 2.44 mg/ml (Mangifera indica, Seed kernel) and 0.22 (Caesalpinia mexicana, fruits) to 2.59 mg/ml (Litchi chinensis, fruit peel) respectively. Fruit of Acacia auriculiformis, Caesalpinia mexicana, Emblica officinalis, fruit pericarp fibres of Cocus nucifera, were also assayed for their specific phenolic composition through HPLC where the amount of caffeic acid varied from 48.5 to 2231 μg/g, chlorogenic acid 63.8 to 912.1 μg/g, ellagic acid 46.4 to 1429.1 μg/g, ferulic acid 36.7 to 762.9 μg/g, gallic acid 181.6 to 2831.6 μg/g, protocatechuic acid 41.7 to 322.8 μg/g, and quercetin 44.6 to 367.6 μg/g. © 2011 IGJPS. All rights reserved
Synthesis, Urease Inhibition, Antimicrobial and Antioxidant Studies of 3,4,5-Trihydroxy Benzoic Acid Derivatives
A series of fourteen 3, 4, 5-trihydroxy benzoic acid were synthesized by schematic route shown in scheme 1 and characterized by spectroscopic analysis. All the newly synthesized derivatives were evaluated for their antim...
Scientific Assessment of Antioxidant Potential of Pyrimidine-2,4(1H, 3H)diones
The aim of present research work is to screen some pyrimidine-2,4-diones for their potential anti-oxidant activity to prevent the progress of free radical mediated disorders using different in-vitro models like nitric ox...
Patents, Health Policy and Access to Medicines
Intellectual property rights are the rights given to person over the creation of their inventions. They usually give the creator as exclusive right over the use of his/her invention for certain period of time, usually 20...
Assessment of Anti-Ulcer Activity of Rheum emodi Rhizomes Extract
A Comprehensive Update on Vascular Dementia: Types, Risk Factors and Management
Vascular Dementia comprises a group of mixed dementing disorders due to cerebrovascular insufficiency and impaired blood supply to the brain. It can be divided into different types depending on the nature of the vascular...