ApoE genotype as risk factors for Alzheimer’s disease in the population of Lublin region, Poland
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2008, Vol 2, Issue 2
Abstract
There is much data concerning ApoE in the pathology of Alzheimer’s disease. This study examines how ApoE genotype contributes to a risk for Alzheimer’s disease in the population of the Lublin region in Poland. The data were obtained as part of a population based BERCAL (Epidemiologic study of Alzheimer’s diseases and other forms of dementia in the population of Lublin region) study. Odds ratios (ORs) and 95% confidence intervals (CIs) for AD, adjusted for age, were calculated for ApoE genotypes. Epsilon3/epsilon3 genotype was the most prevalent genotype in both examined groups. Epsilon2/epsilon2 and epsilon4/epsilon4 were the least prevalent. Among subjects, the risk of AD was significantly reduced for people with genotypes epsilon2/epsilon2. The same significant result was noticed where results were recalculated so that the presence of at least one epsilon2 allele was taken into account, without any epsilon 4 allele in each person. Increased risk with occurrence of epsilon 4 allele is not shown. Increased risk in epsilon 4 carriers was observed. The test did not reach the level of power required. This study suggests that the well known genetic factor, mainly ApoE, even if of noticeable importance, may not be a main risk factor among the population of the Lublin region in Poland.
Authors and Affiliations
Katarzyna Gustaw-Rothenberg
Keywords
Related Articles
- EP ID EP58611
- DOI -
- Views 98
- Downloads 0
Essential oil composition and in vitro biological activity of Achillea millefolium L. extracts
The Achillea genus is one of the widely used genera to treat various medical ailments. In this study, gas chromatography (GS) and Solid Phase Microextraction (SPME) were used to determine the essential oil composition o...
Novel potential of pancreatic-like enzymes of microbial origin in exocrine pancreatic insufficiency – study on a pig model
[b]Introduction.[/b] The standard porcine-derived pancreatic enzyme replacement therapy (PERT) is a lifesaving treatment for patients with diseases causing exocrine pancreatic insufficiency (EPI). An attempt to replace P...
Treatment of lower limb trophic ulcers using hyperbaric oxygenation
[b]Introduction.[/b] Lower limb venous ulcers affect approximately 1–1.3% of the population and constitute the most dangerous and distressing complication related to chronic venous insufficiency. Although the issue of tr...
Isobolographic interaction between AO-294, an enantiomer of losigamone, and valproate in the mouse model of maximal electroshock
The objective of the present study was to determine the exact type of interaction between AO-294, the less active enantiomer of a novel antiepileptic drug losigamone and valproate, in the model of maximal electroshock-in...
Huge isolate abdominal aorta aneurysm in a 24-year-old patient with Marfan syndrome in CT imaging in view of recent literature
The Marfan syndrome is an autosomal dominant disorder of connective tissue characterized by a large number of possible mutations, and by heterogeneity of clinical presentation primarily in skeletal, ocular and cardiovas...