Assessment of Glomerular Filtration Rates by Cockcroft-Gault and Modifcation of Diet in Renal Disease Equations in a Cohort of Omani Patients
Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 14, Issue 1
Abstract
Objectives: Glomerular fltration rate (GFR) is the best index of renal function and is frequently assessed by corrected creatinine clearance (CCLcr). Te limitations of CCLcr have inspired researchers to derive easy formulas to estimate GFR, with Cockcroft-Gault (C-G) and the modifcation of diet in renal disease (MDRD) being the most widely used. Tis study aimed to evaluate the validity of these equations by fnding the relation between CCL cr and estimated GFR (eGFR) by C-G, modifed C-G and MDRD equations. Methods: From 2007 to 2011, 158 subjects were analysed for serum creatinine and CCLcr at Bowsher Polyclinic, Muscat, Oman. Te C-G equation was used to obtain eGFRC-G which was adjusted to body surface area (BSA) to obtain eGFRmC-G, and the MDRD equation was used to obtain eGFRMDRD. Te eGFRMDRD, eGFRmC-G and eGFRC-G were then compared to CCL cr. Results: Te eGFRMDRD, eGFRmC-G and eGFRC-G signifcantly correlated with CCLcr, with a slightly stronger correlation with eGFRMDRD (r = 0.701, 0.658 and 0.605, respectively). A receiver operating characteristic curve analysis showed that the diagnostic accuracy of eGFRMDRD for diagnosing chronic kidney disease (CKD) was higher than that of eGFRmC-G, which in turn was higher than that of eGFRC-G (area under the curve was 0.846, 0.831, and 0.791; cut-off limits were 61.9, 58.3 and 59.5, respectively). Conclusion: C-G and MDRD equations can be an alternative to the CCL cr test for assessing GFR, thus avoiding the need for the cumbersome and expensive GFR test. Te MDRD formula had greater validity than the C-G equation and the C-G equation validity was improved by an adjustment to BSA.
Authors and Affiliations
Magdi E. Al-Osali| Department of Internal Medicine, Al Nahdha Hospital, Muscat, Salim S. Al-Qassabi| Ministry of Health, Muscat, Oman, Saud M. Al-Harthi| Ministry of Health, Muscat, Oman
Keywords
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