Assessment of glycemic control, glucose variability, and hypoglycemic incidence using insulin degludec in children and adolescent with type I diabetes
Journal Title: Medpulse International Journal of Pediatrics - Year 2018, Vol 7, Issue 1
Abstract
Objective: The objective of this study is to study the most recent evidence on glucose variability using insulin degludec comparing it with insulin Glargine in children and adolescents with C-Pepde negative type I Diabetes and to assess the effect of using insulin Deglude on Glucose variability, Hypo and hyperglycemic events, safety and tolerability Design: The current study investigated once-daily insulin degludec versus insulin Glargine, both in combination with bolus insulin aspart in a 36week trial using SMBG and CGM, in children and adolescents with C-Peptide negative Type1DM. Setting Urban Superspeciality hospital and medical college AIIMS (American international institute of medical sciences Udaipur Rajasthan Participants 33 children and adolescents (between 10-18 yrs age) with c-peptide negative i.e less than 0.3 ng/mL type 1 diabetes Main outcome The levels of Fasting Blood Glucose (FBG’s) HbA1c mean value, SDs, blood glucose variability that is blood glucose ≥ 180 and BG < 70 all decreased in Insulin Degludec group. Results: The levels of Fasting Blood Glucose (FBG’s) HbA1c mean value, SDs, blood glucose variability that is blood glucose ≥ 180 and BG < 70 all decreased in Insulin Degludec group. HbA1c reduction was 1.58 in insulin degludec group while HbA1c reduction was 0.92 in insulin glargine group. Fasting blood glucose (FBG’s) was 108 ± 10 mg/dl in insulin degludec group while it was 138 ± 26 mg/dl in insulin glargine patients Conclusions: It is concluded that insulin degludec suppressed daily fluctuations of FBG and PPBG, suppressed the occurrence frequency of hyperglycemia and hypoglycemia, glucose variability and exerted more steady hypoglycemic actions, well tolerated and safe in children and adolescents.
Authors and Affiliations
Akhilesh Bisaria, R E Bhingare, N Pipliwal, Sarvesh Bisaria
Keywords
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