ASSESSMENT OF QTC INTERVAL: A CARDIOVASCULAR RISK FACTOR IN ASYMPTOMATIC TYPEII DIABETICS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 2
Abstract
Background and Objectives: Diabetes Mellitus (DM), metabolic disorder, characterized by hyperglycaemia. There are two main types of diabetes mellitus. Insulin dependent diabetes mellitus (type I DM), Non insulin dependent diabetes mellitus (type II DM). The WHO reports show that 32 million Indian had diabetes mellitus in the year 2000 and the international diabetic federation estimates the number is further set to raise to 69.9 million by 2025 and 80 million by 2030. It is associated with marked increased risk of cardiovascular diseases (CVD), Electrocardiographic (ECG) abnormalities are found to be predictors of silent ischemia in asymptomatic persons. QTC interval measures the duration of electrical activation and recovery of the ventricular myocardium and varies inversely with the cardiac rate. Methods: The study was conducted in department of Physiology, J.J.M Medical College, Davangere, from May 2011 to May 2012. Detailed physical and systemic examination of selected subjects was done. The instrument used to record electrocardiogram is the twelve channels Electrocardiograph. Results: A total of 100 subjects with fifty diagnosed type II DM cases & 50 age and sex matched controls participated in this study. The mean QT interval values (in sec) were 0.40 ± 0.04 and 0.38 ± 0.06 among type II DM cases. There was statistically highly significant increased in QT internal among type II diabetics, mean QTC interval (in sec) was 0.43 ± 0.04 and 0.40 ± 0.06 among Type II DM cases and controls respectively. QTC showed statistically significant increase in type II Diabetics when compared to controls (P<0.05). Interpretation and Conclusion: ECG alterations help to evaluate and detect the sings of myocardial ischemia even in asymptomatic patients, most frequent ECG abnormality in type II diabetic are prolonged QT & QTc intervals. This was a sensitive sign of neuropathy; diagnose CAN, left ventricular hypertrophy due to blood pressure and sudden death. Early detection of QTC will be a good indicator in decreasing the incidence of sudden death due to cardiovascular diseases in diabetics.
Authors and Affiliations
Aftab Begum| Asst. Professor Department of Physiology Basaveshwara Medical College and Hospital. Chitradurga. Karnataka, India., S. Chandrasekharappa| Professor Department of Physiology, JJM Medical College, Davangere, Karnataka, India., Siraj Ahmed Shirbadgi| Asst. Professor Department of Anatomy. Basaveshwara Medical College and Hospital. Chitradurga. Karnataka, India.
Keywords
Related Articles
- EP ID EP2407
- DOI -
- Views 370
- Downloads 24
PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY OF METHICILLIN RESISTANCE STAPHYLOCOCCI ISOLATED IN A TERTIARY CARE HOSPITAL OF RURAL GUJARAT, INDIA
Antibiotic resistance, a global concern, is particularly emerging in developing nations, including India; where the burden of infectious disease is high and healthcare spending is low. Methicillin resistant S. aureus (MR...
Development and Validation of HPLC Method for the Estimation of Anti-HIV Drug Abacavir Sulphate in Bulk and Pharmaceutical Formulations.
Objective: Analytical method development and validation was useful for estimation of drugs in bulk and biological fluids. They help to improve the reliability, consistency and accuracy of analytical data. Present investi...
UMBILICAL ARTERY BLOOD GAS AND LACTATE IN HEALTHY NEWBORNS IN RELATION TO DELIVERY MODE
To establish the reference range of umbilical artery pH, pCO2, pO2 and lactate in healthy newborns in relation to the mode of delivery viz. normal vaginal, instrument assisted and caesarean section.Observational study, c...
EXTRACTION OF BIOACTIVE CHEMICAL COMPOUNDS AND ANTIBACTERIAL ACTIVITY OF BIOWASTE FRUIT PEELS EXTRACTS OF PUNICA GRANATUM
Recently, research has gained a renewed focus on herbal products and their biowaste that play an important role in the developing world due to limited modern health service. Various parts of Punica granatum was shown to...
HPLC Analytical Method Development and Validation Studies of Ondansetron and Rabeprazole.
Objective: Present investigation involves development and validation of chromatographic method for ondansetron and rabeprazole estimation by HPLC. Methods: The present work describes a validated reverse phase high perfor...