Assessment of Relationship Between Calcium-Phosphorus Ratio And Parathyroid Hormone Levels In Serum of Osteoarthritic Disordered Patients: A Diagnostic Protocol
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Introduction: Osteoarthritic disorders (OADs) are degenerative and painful diseases, which found worldwide, also in India. The present study was aimed to determine an association between calcium-phosphorus ratio and parathyroid hormone levels in the serum of patients having OADs. Methods: In the present study, a total 100 patients, aged (40 -≤ 80) years old (female: 73 and male: 27) having OADs in right and/or left knee joints, hip joints, ankle joints and degenerative changes in cervical and lumbar vertebrae as experimental subjects and 100 subjects with same age group (female:male = 73:27) having no OADs in any joint of the body as control subjects were considered. 5ml of peripheral blood samples were taken from each subject of both the groups and serum was used for the analysis of calcium, phosphorus, calciumphosphorus ratio and intact-parathyroid hormone levels. Results: The results were obtained a decreasing level of calcium and phosphorus in the experimental group of combined, female and male subjects compared to that of control group without any significant changes (combined subjects: P=0.16; female: P=0.39; male: P=0.17 for calcium and combined subjects: P=0.02; female: P=0.03; male: P=0.07 for phosphorus). All the data for the calcium-phosphorus ratio of the experimental group of combined, female and male subjects were at significant levels (P<0.01; P<0.05 and P<0.05) in comparison with that of the control group. In the case of i-PTH levels in serum of subjects were shown an increasing trend in the experimental group of combined, female and male subjects at significant levels (P<0.001; P<0.01 and P<0.01) when compared that to control group. The comparative study of each level of calcium, phosphorus, calcium-phosphorus ratio with the i-PTH level in serum of experimental subjects showed lower calcium-phosphorus ratio followed by phosphorus while little higher calcium level but an increasing trend in the i-PTH level in comparison with control group. The comparison results were highly significant between calcium and i-PTH levels (F value = 53.402, P = 0.000), phosphorus and i-PTH levels (F value = 90.261, P = 0.000) and calcium-phosphorus ratio and i-PTH levels (F value = 97.572, P = 0.000) in the serum of experimental subjects. Conclusions: The hypothesis from results showed lower calcium-phosphorus ratio and higher i-PTH levels, which may be a suitable diagnostic protocol to assay OADs besides radiological and MRI imaging
Authors and Affiliations
Apurba Ganguly
Keywords
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- EP ID EP251062
- DOI 10.9790/0853-1612084654
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