Association between sub clinical hypothyroidism and nonalcoholic fatty liver disease in children
Journal Title: Journal of the Indian Medical Association - Year 2019, Vol 117, Issue 7
Abstract
Non-Alcoholic Fatty Liver Disease is defined as accumulation of fat in Liver cells in absence of excess alcohol consumption. To study the association between sub Clinical Hypothyroidism and NonAlcoholic Fatty Liver Disease in Children. In this cross-sectional study which was done at Department of thyroid and endocrine research in the Institute of Nuclear Medicine & Allied Sciences, Delhi, 30 children in the age group of 10-18 years with Sub Clinical Hypothyroidism were compared with 30 age and sex matched controls. This entire cohort of cases and controls were subjected to anthropometric, biochemical and radiological examination. Bio chemical evaluation included estimation of Free T3, Free T4, TSH, lipid profile and Liver Function Tests. Radiological evaluation included USG of thyroid for echogenicity and presence of nodule. USG of abdomen was done to look for presence of fatty liver. In 53.3% children with sub clinical hypothyroidism had fatty liver on USG compared to 13.3% controls. The prevalence of Non-Alcoholic Fatty Liver Disease in our children was considered higher as compared to general population. Children with sub clinical hypothyroidism are at increased risk of developing NonAlcoholic Fatty Liver Disease.
Authors and Affiliations
Rashmi Aggarwal, Manju Popli
Keywords
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