ASSOCIATION OF GLYCATED HAEMOGLOBIN WITH LIPID PROFILE IN TYPE 2 DIABETES PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 4
Abstract
BACKGROUND Diabetes mellitus is one of the common metabolic disorders. It has become a global pandemic with prevalence in both developing and developed countries. Glycated haemoglobin (HbA1c) is used to assess long-term glycaemic control. It indicates the mean plasma glucose level over three months. Patients with type 2 diabetes have an increased prevalence of lipid abnormalities. Dyslipidaemia increases the risk of cardiovascular and cerebrovascular attacks owing to atherosclerosis, controlling hyperglycaemia reduces HbA1c levels and reduces risk of complications resulting due to hyperglycaemia. This study was done to find any association between HbA1c and lipid profile, and thereby HbA1c can be used for screening high risk patients to diagnose dyslipidaemia and timely intervention can avoid complication. MATERIALS AND METHODS This is a descriptive study comprising of 80 non-hypertensive patients with diabetes aged 30 - 60 yrs. attending OPD Department at Mahavir Institute of Medical Sciences with no history of cardiovascular, thyroid, renal or any other organ disorders. The patients were classified into two groups depending on their glycated haemoglobin (HbA1c) as controlled (A1c < 7%) and uncontrolled (A1c >7%) as per ADA guidelines. RESULTS The study included 80 patients. They were further subdivided into two groups based on HbA1c (Group I < 7% and Group II > 7%). Mean ± S.D. of fasting glucose (mg/dL), total cholesterol (mg/dL), triglycerides (mg/dL), LDL-C (mg/dL), VLDL (mg/dL) between Group I and II were (117 ± 18.44 vs. 162 ± 37.66), (150.4 ± 38.26 vs. 175.6 ± 52.26), (118 ± 43.92 vs. 170 ± 99.35), (84.8 ± 29.87 vs. 105.64 ± 36.22), (23.51 ± 8.64 vs. 34.13 ± 20.04) respectively with a statistical significant association of HbA1c with TG, LDL lipid parameter. CONCLUSION Lipid parameters especially cholesterol, triglycerides and LDL-C were raised in uncontrolled group. Significant association between HbA1c and lipid parameters, Triglycerides and LDL were observed. With proper glycaemic control dyslipidaemia can be avoided, thereby reducing risk of atherosclerosis.
Authors and Affiliations
Vithpala Praveena, Sreedevi N. N
Keywords
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- EP ID EP285852
- DOI 10.14260/jemds/2018/99
- Views 95
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