ASSOCIATION OF GLYCATED HAEMOGLOBIN WITH LIPID PROFILE IN TYPE 2 DIABETES PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 4
Abstract
BACKGROUND Diabetes mellitus is one of the common metabolic disorders. It has become a global pandemic with prevalence in both developing and developed countries. Glycated haemoglobin (HbA1c) is used to assess long-term glycaemic control. It indicates the mean plasma glucose level over three months. Patients with type 2 diabetes have an increased prevalence of lipid abnormalities. Dyslipidaemia increases the risk of cardiovascular and cerebrovascular attacks owing to atherosclerosis, controlling hyperglycaemia reduces HbA1c levels and reduces risk of complications resulting due to hyperglycaemia. This study was done to find any association between HbA1c and lipid profile, and thereby HbA1c can be used for screening high risk patients to diagnose dyslipidaemia and timely intervention can avoid complication. MATERIALS AND METHODS This is a descriptive study comprising of 80 non-hypertensive patients with diabetes aged 30 - 60 yrs. attending OPD Department at Mahavir Institute of Medical Sciences with no history of cardiovascular, thyroid, renal or any other organ disorders. The patients were classified into two groups depending on their glycated haemoglobin (HbA1c) as controlled (A1c < 7%) and uncontrolled (A1c >7%) as per ADA guidelines. RESULTS The study included 80 patients. They were further subdivided into two groups based on HbA1c (Group I < 7% and Group II > 7%). Mean ± S.D. of fasting glucose (mg/dL), total cholesterol (mg/dL), triglycerides (mg/dL), LDL-C (mg/dL), VLDL (mg/dL) between Group I and II were (117 ± 18.44 vs. 162 ± 37.66), (150.4 ± 38.26 vs. 175.6 ± 52.26), (118 ± 43.92 vs. 170 ± 99.35), (84.8 ± 29.87 vs. 105.64 ± 36.22), (23.51 ± 8.64 vs. 34.13 ± 20.04) respectively with a statistical significant association of HbA1c with TG, LDL lipid parameter. CONCLUSION Lipid parameters especially cholesterol, triglycerides and LDL-C were raised in uncontrolled group. Significant association between HbA1c and lipid parameters, Triglycerides and LDL were observed. With proper glycaemic control dyslipidaemia can be avoided, thereby reducing risk of atherosclerosis.
Authors and Affiliations
Vithpala Praveena, Sreedevi N. N
Keywords
Related Articles
- EP ID EP285852
- DOI 10.14260/jemds/2018/99
- Views 84
- Downloads 0
SAFETY AND EFFICACY OF MANUAL SMALL INCISION CATARACT SURGERY IN A RURAL HEALTH CARE SETTING IN TAMILNADU
BACKGROUND MSICS demands skill and patience from the cataract surgeon. It is a safe, effective and economical alternative to competing techniques and can be the answer to tackle the large backlog of blindness due to cata...
EARLY LAPAROSCOPIC APPENDICECTOMY IN MANAGEMENT OF APPENDICEAL MASS
BACKGROUND Acute appendicitis is a most common surgical emergency. Approximately, 10% of acute appendicitis patients present with appendiceal mass. Surgical management of appendiceal mass remains controversial. Majority...
EPIDEMIOLOGY OF GALL STONE DISEASE IN A TERTIARY CARE HOSPITAL- A CHANGING TREND IN CURRENT PERSPECTIVE
BACKGROUND Gallstones represent a significant burden for health care systems worldwide. Gallstones occur commonly in the western world. It is the leading cause of inpatient admissions for general surgical practice. The k...
STUDY OF PERCEIVED SOCIAL SUPPORT AND PSYCHOLOGICAL WELL-BEING AMONG PEOPLE LIVING WITH HIV AND AIDS
BACKGROUND People living with HIV and AIDS (PLWHA) face challenges including lack of social support and mental health issues like psychological well-being and quality of life. Coping with HIV may be facilitated by their...
OBSERVATIONAL STUDY ON SUB ARACHNOID BLOCK IN PRE SUBDUED CHILDREN IS A CHEAP, EFFECTIVE, SAFE ALTERNATIVE TO GENERAL ANAESTHESIA
Technically, carrying out Spinal Anaesthesia in adults, may not pose much problems, because of patient co-operation, but same is not always so in case of toddlers and children, because of inherent fear of Hospital...