Attenuation of the Hemodynamic Responses to Endotracheal Intubation with Gabapentin Versus Fentanyl: A Randomized Double Blind Controlled Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background and Aims: Laryngoscopy and tracheal intubation after induction of anaesthesia generate sympathoadrenal responses. We conducted a prospective, double blind, controlled clinical trial to examine whether a single preoperative dose of 800 mg gabapentin would be as effective as 2 micro/kg of intravenous (IV) fentanyl in blunting the hemodynamic response to endotracheal intubation Method: After approval from institutional ethical committee this double blind controlled study was carried out in the department of the anaesthesiology. Sixty patient age 20-60 year were allocated into two groups. One group received 2 micro/kg IV fentanyl ,and other group received 800 mg oral gabapentin. Gabapentin was administered 2 hours and fentanyl 5 min before induction of anaesthesia , Serial values of mean arterial pressure (MAP) and heart rate (HR) were compared among the two group and with the respective pre induction measurement. Result: Patient receiving oral gabapentin 800 mg alone show didn’t remarkable decreases in heart rate and mean arterial pressure in response to endotracheal intubation . These hemodynamic changes were lesser in patient receiving IV fentanyl. Conclusion; It can be concluded from our study that Oral gabapentin does not produce significant reduction in laryngoscopy and endotracheal intubation induced sympathetic responses as compared to IV fentanyl.
Authors and Affiliations
Dr. Rajkamal Sukhadia, Dr. Nipun Lamba, Dr. P S Lamba
Keywords
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- EP ID EP464320
- DOI 10.9790/0853-1802018388
- Views 69
- Downloads 0
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