Beneficial Effects of Ethanolic Seed Extract of Cyperus esculentus on Blood Glucose and Sperm Quality in Alloxan-induced Diabetic Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
Background: An important complication of diabetes mellitus is the disturbance in the male reproductive system. Aim: To determine the effects of ethanolic seed extract of C. esculentus on blood glucose and sperm quality in alloxan-induced diabetic rats. Materials and Methods: Twenty- five (25) normal adult male wistar rats weighing between 150-200g were used. Group I Served as the positive control group and received distilled water only. Groups II- V were the test groups and were induced with diabetes. Group II was the negative diabetic control group with no treatment. Group III received 400mg/kg of C. esculentus. Group IV received 800mg/kg of C. esculentus while Group V received 150mg/kg of standard diabetic drug Metformin. Their fasting blood glucose levels were estimated. The animals were sacrificed and the semen sample was collected for sperm analysis. Results: Significant (P<0.05) increase in blood glucose level in group II (108.00±3.52 mg/dL) and significant decrease in group IV (57.0±2.49 mg/dL) when compared with the control group I (74.60±1.63 mg/dL). No significant difference in blood glucose was observed in groups III (79.0±3.07 mg/dL) and V (77.0±2.55 mg/dL) when compared with the control group I. There was significant decrease (P<0.05) in sperm count in group II (3.80 ± 0.22 x106 /mL) and significant increase in group IV (7.68 ± 0.20 x106 /mL) when compared with the control group I (6.16 ± 0.26 x106 /mL). There was no significant difference (P>0.05) in sperm count in groups III (6.28 ± 0.19 x106 /mL) and V (5.60 ± 0.19 x106 /mL) when compared with control group I. The sperm motility and morphology significantly decreased in group II but significantly increased in group IV when compared with control group I. Groups III and V showed no significant difference in sperm motility and morphology when compared with the control. Conclusion: C. esculentus seed extract may be beneficial in diabetes mellitus as well as its deleterious effect on sperm quality.
Authors and Affiliations
Njoku-Oji N. N, Ifegwu N. O, Umahi G. O, Sobanke A. O, Uchefuna R. C
Keywords
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- EP ID EP444252
- DOI 10.9790/3008-1401018490.
- Views 52
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