Benefits of alpha-ketoglutarate versus succinate on rat muscle dysfunction as a result of exposure to a uremic environment[sub][/sub]
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
Muscle weakness is a prominent feature of end-state renal failure. While the cause of this strongly disabling muscle condition is at present unknown, there are suggestions that metabolic factors may play a role in this type of muscle fatigue. In vitro measurements of muscle function of the fast-twitch extensor digitorum longus (EDL) muscle of adult rats was performed. Isolated muscles were exposed to either a normal ionic environment, a uremic environment – with and without alpha-ketoglutarate (AKG), or with and without succinate, before being field stimulated until they were almost totally fatigued. The addition of AKG to the uremic environment was found to restore muscle performance so that the muscles no longer differed significantly from those incubated in a normal ionic environment. Similar effects to those noted for AKG were observed for succinate. It is concluded that AKG and succinate have a positive and restorative effect on muscle fatigue in uremic fast skeletal muscles in vitro. This beneficial form of treatment is proposed to act at the in vitro isolated muscle level by means of phosphate-binding, as the literature shows that an elevated plasma Pi concentration with renal failure disrupts normal muscle function.
Authors and Affiliations
Else M. Bartels, Stefan G. Pierzynowski, Adrian P. Harrison
Keywords
Related Articles
- EP ID EP58571
- DOI -
- Views 91
- Downloads 0
Hobnail hemangioma of the skin in a juvenile patient
Hobnail hemangioma is a rare, benign, vascular lesion with peculiar but commonly misleading morphology, located mostly on the extremities or trunk, and affects young and middle-aged adults with a slightly male predominan...
Influence of oxcarbazepine and its combination with SIB-1893 on body temperature in rats
The aim of the study was to determine the effects of oxcarbazepine (OXC – a newer antiepileptic drug) administered alone and in combination with SIB-1893 (a selective non-competitive metabotropic glutamate subtype 5 [mG...
Isobolographic interaction between AO-294, an enantiomer of losigamone, and valproate in the mouse model of maximal electroshock
The objective of the present study was to determine the exact type of interaction between AO-294, the less active enantiomer of a novel antiepileptic drug losigamone and valproate, in the model of maximal electroshock-in...
Quercetin: health benefits with relevance to TNF-α-linked inflammatory diseases
With increasing interest among the general public for using natural and herbal remedies, there is a great need to document and list ancient medical texts and practices, as well as to investigate the efficacy of a number...
Features of the first alcohol test – subsequent attitude of 6 th year students at the State Medical University in Grodno, Belarus
[b]Objective.[/b] To clarify the mechanism of initiation of young people to alcohol, determine what factors influence this process, and identify the particular attitude to alcohol at a young age. [b]Materials and metho...