Isobolographic interaction between AO-294, an enantiomer of losigamone, and valproate in the mouse model of maximal electroshock
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
The objective of the present study was to determine the exact type of interaction between AO-294, the less active enantiomer of a novel antiepileptic drug losigamone and valproate, in the model of maximal electroshock-induced convulsions in mice. Isobolographic analysis of obtained data show that the 2 drugs interact additively. This may suggest that AO-294 may be used in the 2-drug therapy of refractory epilepsy. However, it does not seem to be superior to its maternal antiepileptic, since losigamone (according to previous reports) interacted synergistically with valproate.
Authors and Affiliations
Kinga K. Borowicz, Bożena Jaszczyk
Keywords
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