Biosensor Platforms for Cancer Derived Exosomes Detection
Journal Title: Yeni Yuzyil Journal of Medical Sciences - Year 2021, Vol 2, Issue 3
Abstract
Early diagnosis is one of the biggest challenges in the fight against cancer. Traditional cancer diagnosis methods have some disadvantages such as requiring expertise, involving invasive procedures, radiation exposure, high cost and loss of time. For this reason, current research has focused on the development of faster, reliable and cost-effective diagnostic methods. The use of biomarkers present in body fluids has been promising in this regard. Exosomes secreted by cells into body fluids and responsible for intercellular communication are biological nanoparticles produced by natural pathways. Studies have shown that the change in microenvironmental conditions during tumor development changes exosome secretion. Due to their high cellular activities, tumor cells produce a much higher rate of exosome than healthy cells. Therefore, it is known that the number of exosomes in body fluids is significantly enriched compared to other cells and can act as a diagnostic biomarker alone. Cancer-derived exosomes are very interesting for early detection of cancer and evaluation of therapeutic response. Biosensor is an analytical device used to detect an analyte that combines a biological component with a physicochemical detector. Nowadaysthere is an increasing interest in developing cancer biosensors with superior analytical performance and real-time measurement. The development and dissemination of biosensor applications for exosome detection will be very advantageous for individuals in regions where there is no access to diagnostic devices and resources. Considering the disadvantages of traditional methods, we can say that biosensor studies are much more advantageous because they are cheaper, provide multi-analyte support, provide high sensitivity, and obtain fast and reliable results. In this study, recent developments in biosensor systems for the detection of exosomes secreted from different cancer cells are summarized. In addition, the use of cancer-secreted exosomes for point of care testing (POC) and the challenges in this area are presented and discussed.
Authors and Affiliations
Kübra KELLECİ, Sevil ÖZER
Keywords
Related Articles
- EP ID EP698169
- DOI https://doi.org/10.46629/JMS.2021.45
- Views 86
- Downloads 0
Gücün Kötüye Kullanımı Bağlamında Cinsel İstismara Genel Bir Bakış
Cinsel istismar, Dünya’nın her yerinde mekân, mağdurun ve saldırganın mesleği, sosyo-ekonomik ve eğitim durumu, dili, dini, ırkı, ve toplumdaki konumu gibi birçok faktörden bağımsız olarak meydana gelmektedir. Birçok...
Neuroscience & training practices
Is it true that adults are less able than children to learn because their brain is less plastic? Yes, it is. However we can learn at every ages and science can help in the matter. Here is an example which shows what...
Sensörinöral İşitme Kaybında Gen Terapi Yaklaşımları
İşitme kaybı, insanın sosyal ve bilişsel gelişimini ciddi şekilde etkileyen dünya genelinde görülen en yaygın halk sağlık problemlerinden biridir. İleri derece işitme kaybı ile karakterize edilen sensörinöral işitme k...
Sarkopenik Obezitede Egzersiz Yaklaşımları
Sarkopenik obezite prevalansı, özellikle yaşlanan bireyler arasında dünya çapında artış göstermektedir. İskelet kası kütlesi ve fonksiyonundaki azalma (sarkopeni) ve yağ kütlesindeki artış (obezite), kronik hastalıklar...
Damar İçi Madde Bağımlısı Hastalarda Akla Gelmesi Gereken Bir Olasılık; İnfektif Endokardit
İnfektif endokardit (İE), kardiyak valvlerin ve/veya duvar endokardının patojen mikroorganizmalarca enfeksiyonudur. Yüksek morbidite- mortalite nedeniyle önemini korumaktadır. Bulguların spesifik olmayışı, mikroorgan...