Blueberry Tea Enhances Insulin Sensitivity by Augmenting Insulin-Mediated Metabolic and Microvascular Responses in Skeletal Muscle of High Fat Fed Rats
Journal Title: International Journal of Diabetology & Vascular Disease Research (IJDVR) - Year 2013, Vol 1, Issue 8
Abstract
Background: The aim of the current study was to determine whether a unique blueberry tea (BT) ameliorates insulin resistance by improving metabolic and vascular actions of insulin in skeletal muscle. Methods: Male Sprague Dawley rats were fed normal (4.8% fat wt/wt, ND) or high (22.6% fat wt/wt, HFD) fat diets for 4 weeks. A second group of HFD rats was provided BT (4.0% wt/vol) in the drinking water during the final 2 weeks. Animals were subjected to an intraperitoneal glucose tolerance test (1g glucose/kg IPGTT) or euglycaemic hyperinsulinaemic clamp (10mU/min/kg x 2hr). Results: HFD rats displayed significantly (p<0.05) higher plasma glucose levels at 15 and 30 mins following the IPGTT compared to ND, and this increase was completely abolished by BT treatment. Glucose infusion rate, muscle glucose uptake, and microvascular perfusion in muscle were significantly (p<0.05) impaired during clamps in HFD and all markedly improved (p<0.05) with BT treatment. Insulin-mediated changes in femoral artery blood flow were unaffected by HFD or BT treatment. Conclusions: We conclude that BT treatment ameliorates glucose intolerance and insulin resistance by restoring both metabolic and microvascular insulin sensitivity in high fat-fed rats. Therefore, BT consumption may have therapeutic implications for insulin resistance and type 2 diabetes.
Authors and Affiliations
Michelle A. Keske
Keywords
Related Articles
- EP ID EP197825
- DOI 10.19070/2328-353X-130006
- Views 120
- Downloads 0
Obesity and Renal Prognosis (Assessed by Albuminuria and eGFR) in Type 2 Diabetics in Kinshasa
Background: Obesity is associated with greater survival in end stage renal disease (ESRD). Objective: To assess the association between cardiovascular risk factors and renal Prognosis, assessed by eGFR and albumin/creati...
Rhabdomyolysis as an Unusual Complication of Hyperosmolar Hyperglycemic State
Objectives: Hyperosmolar hyperglycemic state (HHS) is one of the serious metabolic derangements that occurs in patients with diabetes mellitus, Cases associated with hyperosmolarity due to diabetic ketoacidosis or hypero...
Effect of Aqueous Extracts of some Ayurvedic Medicinal Plants on Tissues Involved in Glucose Homeostasis in vitro
Aqueous extracts of some antidiabetic Ayurvedic plant treatments such as Trigonella foenum-graecum Linn (TFG), Pterocarpus marsupium Roxb (PM), Gymnema sylvestre R.Br (GS) and Curcuma longa Linn (CL) were tested for thei...
Link between Hyperhomocysteinemia, Glycemic and Lipid Profiles, in Type 2 Diabetes in Côte d'Ivoire
The hyperhomocysteinemia is associated with the development and the accentuation of the cardiovascular complications of the type 2 diabetes. Several studies had established a link between the hyperhomocysteinemia, the dy...
Pathophysiologic Aspects of Hypertension
Hypertension is defined as a sustained increase in blood pressure. Historically, the level of blood pressure designating hypertension has been a systolic blood pressure of 140 mm Hg or more and/or a diastolic blood press...