Cervical cancer : Promoter hypermethylation and its reversal
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
Cervical cancer is one of the most common cancer in women resulting in 0.4% of the total mortality across the world. A number of epigenetic alterations occur during all stages of cervical carcinogenesis including global DNA hypomethylation, hypermethylation of the tumor suppressor genes, and histone modifications, like acetylation, deacetylation, phosphorylation, methylation etc. Many genetic and environmental factors lead to the development of cervical cancer, but DNA methylation may provide a link between these factors. Genome stability and normal gene expression are largely maintained by a fixed and predetermined pattern of DNA methylation. The reversible nature of epigenetic changes constitutes a target for transcriptional therapies, namely DNA methylation and histone deacetylase inhibitors. The near future is likely to bring long-awaited answers on the impact of aberrant epigenetic information caused by diet and environment and provide important information for the discovery of new biomarkers andthe development of novel strategies for diagnosis and prevention, of cervical cancer which is the most common cancer affecting developing nations. This review encompasses the epigenetics of cervical cancer and the recent discoveries till now in the field of the reversal of epigenetic changes, which in turn would lead to a significant step in the direction of therapy against this dreaded disease.
Authors and Affiliations
Abhimanyu Kumar Jha 1 , 2 , Mo h s e n Ni k b a k h t 1 , Ne e n a Ca p a l a s h 1 q , Jagde ep Kaur 1 * q
Keywords
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