Chronic fatigue syndrome: clinical and pathophysiological, diagnostic and defferential diagnostic aspects (literature review and data of own observations). Part 1
Journal Title: Український терапевтичний журнал - Year 2019, Vol 0, Issue 2
Abstract
Objective — to provide an analytical overview of the most important sources of literature and to present the materials of 15 years of own experience in the study of the chronic fatigue syndrome (CFS). The CFS is a systemic disease characterized by prolonged severe fatigue, cognitive dysfunction, pain of different localization, worsening of working capacity and quality of life. Its prevalence in the world is constantly rising and causing significant damage to the international community. This disease is considered to be one of the new challenges facing modern medicine worldwide. Scientists from the leading scientific centers have established that CFS is a highly concentrated stable and longterm hypometabolic response of the body to external stressors, which systemically manifests itself at levels from central nervous structures to mitochondria. This disease is accompanied by significant and persistent immune disorders, cytokine dysregulation, lowlevel systemic inflammation, the degree of which correlates with severity of CFS manifestations and prolonged course. The Bourne disease virus and various types of herpesviruses are often detected at CFS, but most scientists consider them as pathogenetic triggers of CFS exacerbations. It is believed that the carried out investigations will open new prospective ways to improve the CFS treatment. Various names of CFS are discussed: «myalgic encephalomyelitis», «systemic intolerance to stress». It is noted that nowadays there are no reliable laboratory criteria for the CFS diagnosis and effective treatment regimens. The authors of the article give an indicative scheme of pathogenesis of CFS and diagnostic and differential — diagnostic algorithm of this disease. The syndrome of chronic fatigue is condition that is insufficiently researched and not widely known by the general medical community; its incidence is constantly increasing worldwide, and methods of its diagnosis and treatment are poorly effective and require improvement.
Authors and Affiliations
O. I. Voloshyn, N. V. Bachuk-Ponych, L. O. Voloshyna, V. P. Prysyazhnyuk, V. L. Vasyuk, I. V. Okipnyak
Keywords
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- EP ID EP634377
- DOI 10.30978/UTJ2019-2-87
- Views 103
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