Evaluation of changes and diagnostic informative of the cytokine profile in young patients with gastroesophageal reflux disease, occurring against the background of autoimmune inflammation
Journal Title: Український терапевтичний журнал - Year 2019, Vol 0, Issue 3
Abstract
Objective — to determine the general trend of changes in the indicators of systemic inflammation, interleukin 1β (IL 1β) and interleukin 18 (IL 18) in patients with gastroesophageal reflux disease and autoimmune thyroiditis in young people. Materials and methods. The study of the role and levels of IL 1β and IL 18 involved 83 young patients (students from 18 to 25 years) with gastroesophageal reflux disease (GERD) and autoimmune thyroiditis (AIT). The comparison group consisted of 30 patients with isolated GERD of the matched age, gender, and form of the disease. Results and discussion. It has shown that the GERD was accompanied by a significant increase of IL 1β levels, in association with AIT this indicator increased in 1.7 times. It was established that the value of IL 1β depended on the form of the esophageal mucosa lesions, it was more pronounced in the presence of erosion, but did not correlate with their number. In patients with GERD and AIT, the IL 18 levels were increased up to 1761.5 (1451.7; 2876.9) pg/ml, which exceeded this values for patients with isolated GERD: 614.6 (521.9; 721.8) pg/ml and control values (p < 0.05). Conclusions. The increased IL 18 levels have been reveled in patients with GERD and AIT, due to the inflammatory process in both organs and an autoimmune process in the thyroid gland. Further disease progression may occur due to the preservation of the autoimmune component. The GERD course, especially at it combination with AIT in young people, was accompanied by increased IL 1β levels in peripheral blood, thus indicating the presence of an active inflammatory process.
Authors and Affiliations
T. M. Pasiieshvili
Keywords
Related Articles
- EP ID EP666913
- DOI 10.30978/UTJ2019-3-16
- Views 91
- Downloads 0
Effects of nicotinic acid on phosphorus-calcium metabolism in patients with diabetic nephropathy
Objective — to study the effects of therapy with the use of nicotinic acid on the clinical and laboratory parameters and the levels of FGF23, calcium and phosphorus in the serum of patients with diabetic nephropathy (DN)...
Hypolipidemic efficacy of probiotic Lactobacillus plantarum in patients with coronary heart disease
Objective — to evaluate the lipidlowering effect of probiotics Lactobacillus plantarum by comparing the efficacy of the combination of this probiotic and simvastatin with simvastatin monotherapy in patients with coronar...
Correction of indicators of oral fluid in patients with bronchocardial pathology
The oral pathology treatment against the background of somatic diseases is important problem of modern dentistry. It is known that negative drug effects of somatic diseases basic therapy have different clinical manifesta...
Overweight and obesity as important risk factors for cytostatic-induced liver injury in patients with acute leukemia
Objective — to determine the role of overweight and obesity in the hepatotoxic reactions development in patients with acute leukemia (AL). Materials and methods. The examinations involved 58 patients with newly diagnosed...
Galectin 3 — a novel biomarker for chronic heart failure in the patients with ischemic heart disease and concomitant gastroesophageal reflux disease
Objective — to study the role of the biomarker for chronic heart failure (CHF) Galectine 3 (Gal 3) in patients with IHD and concomitant gastroesophageal reflux disease (GERD). Materials and methods. The study involved 10...