Bile acids content in brain of common duct ligated rats

Introduction. Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Bile duct ligated rats constitute an interesting model to study the mechanism of cholestasis, and its action on seve...

Andres Blei (Andy) October 1949-October 2008

Is gallbladder cancer decreasing in view of increasing laparoscopic cholecystectomy?

Background. Gallstone disease affects over 20 million people in the U.S. and is a major risk factor for gallbladder cancer (GBC). In 1988, a less invasive, low-cost procedure, laparoscopic cholecystectomy (LC), was intro...

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The role of zinc in liver cirrhosis

Zinc is an essential trace element playing fundamental roles in cellular metabolism. It acts mostly by binding a wide range of proteins, thus affecting a broad spectrum of biological processes, which include cell divisio...