Is gallbladder cancer decreasing in view of increasing laparoscopic cholecystectomy?
Journal Title: Annals of Hepatology - Year 2011, Vol 10, Issue 3
Abstract
Background. Gallstone disease affects over 20 million people in the U.S. and is a major risk factor for gallbladder cancer (GBC). In 1988, a less invasive, low-cost procedure, laparoscopic cholecystectomy (LC), was introduced and became the standard of care for management of gallstones. Methods. GBC incidence (1973-2007) and mortality rates (1969-2006) were calculated using SEER Program data. LC rates (1993-2008) were obtained from NAMCS, NHAMCS, and HCUP. Annual percent change was estimated by gender, age, and race, and the statistical significance was assessed at p < 0.05. Correlation analysis was performed on GBC and LC trends. Results. Since the early 1970s, GBC incidence and mortality rate have declined. Women and older age groups continue to have the highest risk for GBC, despite having greater declines. Incidence significantly decreased among whites, but did not among blacks. The number of inpatient LC procedures increased by 15% between 1994 and 2008; however, inpatient and outpatient LC rates remained stable. LC rate was not significantly correlated with either GBC incidence or mortality. Conclusions. The decline in incidence and mortality of GBC began decades before the introduction of LC and apparently has stabilized in the past decade. No temporal relationship existed between LC rate and the incidence and mortality rates of GBC. Our study suggests that prevention of a rare tumor may be extremely difficult if the surgical removal of a risk factor is involved.
Authors and Affiliations
My Di Le, Donald Henson, Heather Young, Jorge Albores-Saavedra
Keywords
Related Articles
- EP ID EP78046
- DOI -
- Views 133
- Downloads 0
Combined high-fat diet and sustained high sucrose consumption promotes NAFLD in a murine model
Background. The study of NAFLD in humans has several limitations. Using murine models helps to understand disease pathogenesis. Aim. Evaluate the impact of 4 different diets in the production of NAFLD with emphasis on a...
Hepatitis B virus prevalence and vaccination response in health care workers and students at the Federal University of Bahia, Brazil
Background and rationale for the study. Hepatitis B (HB) is one of the most prevalent occupational infections in health attendance environments. According to the Brazil Ministry of Health, health professionals must be va...
Reversibility of liver fibrosis
Liver cirrhosis is a major cause of morbidity and mortality worldwide and has very limited therapeutic options. Regardless of the aetiology, hepatic fibrosis is a characteristic feature of chronic liver disease. Our know...
Wait Time for Curative Intent Radio Frequency Ablation is Associated with Increased Mortality in Patients with Early Stage Hepatocellular Carcinoma
-
Association between butyrylcholinesterase activity and low-grade systemic inflammation[sub][/sub]
Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported...