Clinical, gross, histopathological study and tumor marker estimation of ovarian lump
Journal Title: Medpulse International Journal of Pathology - Year 2019, Vol 9, Issue 1
Abstract
Background: Ovarian disease of surgical importance has been divided into non-neoplastic cysts, inflammation and neoplasm. Majority of ovarian masses are benign (80%), with cystic, solid or mixed characteristics and a favorable prognosis. The other 20% of these masses are malignant tumors. Aims and objectives: To study the histopathology and tumor marker positivity of ovarian tumors. Material and methods: Resected specimens of ovarian mass were collected from the department of Obstetrics and Gynecology of four different surgical centres and macroscopic and microscopic examination of these specimens was done between 2012-2016The Alpha-Fetoprotein (AFP), The Carcinoembryonic Antigen (CEA) and hCG were measured using ELISA Kit. Results: It was observed that out of 50 ovarian masses, 36 (72%) cases were benign and 14 (28%) were malignant. Of all the 14 cases of malignant ovarian cancer, 11 were found to be of epithelial origin. 2 cases were of Germ cell and 1 of Sex cord/Stromal cell origin. Serous cystadenocarcinoma was seen in 4 (28.5%) cases of at malignant lumps. Next to it was Endometriod tumor seen in 3(21.4%) cases. Mucinous cyastadenocarcinoma was seen in 2 cases only. Of all the 34 cases of the Epithelial tumor, the majority, 30 cases, Were in the age group of 21 to 50 years. Sax cord/Stromal cell tumor and Dermoid cysts were also seen predominantly in the reproductive age group. Dysgerminoma was interestingly found to be present in the younger age group. Of the 2 cases seen one was be 10 years of age and other in the 2nd decade of life. All the cases of Non-neoplastic cysts were seen in the age group of 21- 50years. Conclusion: To conclude majority of the ovarian lump were of epithelial origin. In 74% cases the lump was found to be benign. In the remaining 26% cases, it was malignant.The incidence of benign tumor was highest between 21-40 years. On the other hand the highest incidence of malignant tumor was in between 35 to 55 years.CEA, β-hcG, AFP are not sensitive markers in ovarian cancer as they are present in very few number of cases but are specific markers as CEA for mucinous tumors, clear cell tumor, brenners. AFP for yolk sac tumor, beta hcG for dysgerminoma.
Authors and Affiliations
Hari Shankar Mishra, Shiv Kumar Mishra
Keywords
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- EP ID EP456321
- DOI 10.26611/105913
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