Clinical importance of hyperhomocysteinemia in patients with ischemic stroke
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 1
Abstract
<b>Introduction. </b>Homocysteine is an amino acid, produced during the metabolism of methionin to cystein. A high concentration of total homocysteine is a strong and independent risk factor for cardiovascular diseases.<br><b>Aim.</b> The aim of the study was to analyze the homocysteine concentrations in the blood of patients in the early stage of stroke according to clinical assessment in the Oxfordshire Community Stroke Project (OCSP) classification.<br><b>Material and methods. </b>We examined the sera of 193 patients in the early stage of stroke. Total plasma homocysteine concentrations were measured by fluorescence polarisation immunoassay (FPIA-ABBOTT).<br><b>Results. </b>We did not find statistical difference of concentration of homocysteine between control group vs group of stroke patients. We found an increased pathological homocysteine concentration in 35.3% subjects and compared to the total number group of examined stroke patients this concentration was significantly higher in the (lacunar circulation infarct) LACI group (P < 0.007). A homocysteine concentration > 15 μmol/l was observed in 41.9% of LACI patients. This was the highest statistically significant concentration (P < 0.02) compared to the other groups of patients.<br><b>Conclusions.</b> Our results determined the association of lacunar stroke with an increased homocysteine concentration as independent risk factor.
Authors and Affiliations
Witold Palasik, Wiesław Tadeusiak, Urszula Fiszer
Keywords
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