Clinical importance of hyperhomocysteinemia in patients with ischemic stroke
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 1
Abstract
<b>Introduction. </b>Homocysteine is an amino acid, produced during the metabolism of methionin to cystein. A high concentration of total homocysteine is a strong and independent risk factor for cardiovascular diseases.<br><b>Aim.</b> The aim of the study was to analyze the homocysteine concentrations in the blood of patients in the early stage of stroke according to clinical assessment in the Oxfordshire Community Stroke Project (OCSP) classification.<br><b>Material and methods. </b>We examined the sera of 193 patients in the early stage of stroke. Total plasma homocysteine concentrations were measured by fluorescence polarisation immunoassay (FPIA-ABBOTT).<br><b>Results. </b>We did not find statistical difference of concentration of homocysteine between control group vs group of stroke patients. We found an increased pathological homocysteine concentration in 35.3% subjects and compared to the total number group of examined stroke patients this concentration was significantly higher in the (lacunar circulation infarct) LACI group (P < 0.007). A homocysteine concentration > 15 μmol/l was observed in 41.9% of LACI patients. This was the highest statistically significant concentration (P < 0.02) compared to the other groups of patients.<br><b>Conclusions.</b> Our results determined the association of lacunar stroke with an increased homocysteine concentration as independent risk factor.
Authors and Affiliations
Witold Palasik, Wiesław Tadeusiak, Urszula Fiszer
Keywords
Related Articles
- EP ID EP54286
- DOI -
- Views 128
- Downloads 0
Platelet concentrates, as new and promising agent in the orthopedic surgery – an introduction
Tissue healing is a complex process, involving numerous interactions between cells, that are mediated by signal molecules, including growth factors. The commonly used source of growth factors in orthopedics and trauma su...
Genetic polymorphisms of endothelial nitric oxide synthase in children with primary hypertension
Nitric oxide (NO) is the main substance regulating vascular tone. Endothelial dysfunctionand decreased production of NO is a well-known phenomenon in adults withcardiovascular disease and especially when concomitant diso...
Osteoporosis in chronic inflammatory joint diseases
Bone complications, including periarticular erosions as well as local and generalized osteoporosis, are typical symptoms of chronic inflammatory joint diseases and can lead to increased fracture risk. Recent findings sho...
Miastenia u osób starszych
Miastenia (Myasthenia gravis, MG) jest najczęstszym pierwotnym schorzeniem złącza nerwowo-mięśniowego. W przypadkach typowych spowodowana jest występowaniem przeciwciał przeciwko receptorom acetylocholinowym. Dominującym...
EEG paroxysmal patterns
ntroduction. This paper is concentrated on the problems of identification and qualification of the paroxysmal EEG patterns. The problem is discussed in relation to commonly accepted guidelines concerning description and...