Clinical Profile and Role of VEGF-C (+936c/T) Polymorphism in Prognosis and Management of Oral Squamous Cell Carcinoma.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
Aims: Angiogenesis and lymph angiogenesis are necessary step in tumour growth and metastasis. Vascular endothelial growth factor (VEGF-c) is a major mediator of oral squamous cell carcinoma angiogenesis and lymphangiogenesis. Therefore, we investigated the association of one polymorphism (+936 C/T) in the VEGF-c gene with oral squamous cell cancer risk and prognostic characteristics of the tumour in a case-control study. Experimental Design: We examined one polymorphism in the VEGF –c gene (+936C/T) in 75 oral squamous cell cancer cases and 75 controls from Kanpur, Uttar Pradesh, India and adjacent areas together with geographically selected controls. Results: None of the polymorphism or any halotype was significantly associated with either oral squamous cell cancers. Our study suggests that the +936C/T polymorphism is unlikely to be associated with oral squamous cell cancer. We also analysed the cases for genotypes or halotypes that associated with tumour characteristics. The genotypes and halotypes were not related with other tumour characteristics such as regional and distant metastasis, stage at diagnosis. Conclusion: In our study, the most common site for oral squamous cell carcinoma (OSCC) was buccal mucosa associated with tobacco chewing. Although +936 C/T polymorphisms studied in the VEGF-c gene was not found to influence susceptibility to oral squamous cell cancer significantly in our study but some of the VEGF-c genotypes and halotypes may influence angiogenesis and lymph angiogenesis.
Authors and Affiliations
Dr. Arvind Kumar Sharma
Keywords
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