Clinical Study on Interstitial Lung Diseases in a Tertiary Teaching Hospital of North Kerala
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 1
Abstract
Introduction: Interstitial lung disease (ILD) is a group of conditions affecting the lung parenchyma. The American Thoracic Society/European Respiratory Society classified the idiopathic interstitial pneumonias (IIPs) into seven specific entities and offered standardized terminology and diagnostic criteria. Review of literature shows the stress on the necessity of finding a better clinical algorithm in the diagnosis and management of IIPs. Aim: To study the demography, risk factors, clinical features, laboratory, and radiological investigations in the diagnosis of ILDs in patients attending the tertiary teaching hospital of North Kerala. Materials and Methods: A total of 82 patients were studied for their demography, risk factors, clinical features, laboratory, and radiological investigations in the diagnosis of ILDs in a tertiary teaching hospital. Laboratory tests, X-ray chest, high-resolution computed tomography (HRCT), pulmonary function tests, 6-min walk test, bronchiolar lavage analysis, and lung biopsy were done. Patients were categorized as autoantibody positive if they had one or more circulating autoantibody levels above the established reference values except antinuclear antibody and rheumatoid factor (RF). Results: C-reactive protein values in 32 patients (45.07%) showed values of 1.84 ± 4.60 mg/dL. RF values in 11 patients were 102.24 ± 11.25. HRCT in 67 patients showed features of non-specific ILD in 17 and idiopathic pulmonary fibrosis (IPF) in 28. Anti ribonucleoprotein antibody test was negative in 31.37%, borderline in 52.94%, and positive in 15.68%. Conclusions: IPF was the most common ILD in the study followed by non-specific interstitial pneumonia, desquamative interstitial pneumonia, and cryptogenic organizing pneumonia. Multidiscipline discussion and investigative approach helps in diagnosis and assessing the prognosis of ILD. The inclusion of environmental exposure factors conducted in a prospective method would go a long way to provide further insight into the etiology and diagnoses of ILD.
Authors and Affiliations
M Sanjeev Kumar
Keywords
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