Clinicopathological study of neoplastic and non-neoplastic lesions of prostate- two years study
Journal Title: Indian Journal of Pathology and Oncology - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Among the cancer related deaths in men, prostatic cancer is the second most common to lung cancer. Important cause for prostatic morbidity and mortality includes inflammation, benign nodular enlargement and tumors. Histopathological diagnosis and grading plays a definitive role in the management of prostatic cancer. The current study aims at analyzing clinicopathological features of various neoplastic and non-neoplastic lesions of the prostate. Materials and Method: The present study included 158 prostatic specimens, which comprises of 157 TURP chips, and 1 prostatectomy specimen. The results were grouped into non-neoplastic and neoplastic lesions. The cases of prostatic adenocarcinoma were graded using Gleason microscopic grading. Results: Out of 158 prostatic specimens studied; 145 were benign lesions, 4 were premalignant and 9 were malignant lesions. Among benign lesions nodular hyperplasia without prostatitis was the most common. The cancer detection rate with prostatic volume < 40 ml was higher than with >40 ml. Most malignant prostatic lesions showed marked elevation in serum PSA levels (>20 ng/ml). Among the malignant lesions, commonest lesion was prostatic adenocarcinoma. Discussion: Since low-grade lesions are usually asymptomatic, awareness of serum PSA level estimation, digital rectal examination should be done among elderly males who are prone for malignancy. Male individuals with a positive family history for prostatic carcinoma must undergo relevant screening test.
Authors and Affiliations
SD Birare, SK Mahule, KT Dalve, NR Patil, NV Naigaonkar
Keywords
Related Articles
- EP ID EP318130
- DOI 10.18231/2394-6792.2017.0133
- Views 43
- Downloads 0
Morphological patterns of FNAC of lymph nodes
Introduction Fine needle aspiration cytology is fast becoming preoperative method of choice for diagnosis and management of various lumps and lesions since few decades It helps clinician to decide mode of treatment in mo...
Frozen section as a guide in intra operative decision making in management of adnexal mass lesions
Ovarian tumours present with vague pelvic abdominal and menstrual symptoms Lack of histological diagnosis before hand with no definite evidence of malignancy intra operatively may put the surgeon at the cross roads wheth...
Utility of manually constructed large core micro-array for routine immunohistochemical assessment of ER, PR and HER2 in carcinoma breast
Aim: To compare Immunohistochemistry (IHC) results of large core Tissue micro array (TMA) with the conventional whole section for estrogen receptor (ER), progesterone receptor (PR) and HER2 expression in breast carcinoma...
A rare case of Anaplastic Large Cell Lymphoma
Anaplastic large cell lymphoma is defined by a proliferation of large pleomorphic blasts and a constant expression of the CD30 molecule on all neoplastic cells, and has been clinically subdivided into a primary form and...
Primary mesenteric fibromatosis: Report of a sporadic case
Mesenteric fibromatosis or intra-abdominal desmoid tumour is a rare neoplastic, monoclonal myofibroblastic proliferative disease affecting the mesentry which is prone to aggressive local recurrences, but lacks metastatic...