Clinicopathological study of synovial biopsies at tertiary care hospital and its diagnostic utility
Journal Title: Indian Journal of Pathology and Oncology - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Arthritis, an important cause for morbidity, is commonly found in clinical practice. Diseases such as tuberculous synovitis and gout need treatment directed towards specific diagnosis which can be achieved by the use of relatively simple technique of arthroscopic synovial aspiration and biopsy. Aim and Objectives: To study the histomorphological spectrum of different clinically suspected synovial lesions and to assess diagnostic utility of synovial biopsies. Materials and Method: The present study comprises analysis of 100 biopsies of clinically suspected synovial lesions during period of 4 years. Relevant clinical details were obtained. Synovial biopsy specimens were processed routinely and wherever necessary special stains like Z-N stain for AFB, Prussian blue stain for haemosiderin and immunohistochemical studies were carried out.. Wherever necessary the available clinical and radiological findings were taken into consideration to categorize the lesions. Lesions were classified under main categories of inflammatory joint diseases, degenerative joint disease, tumor and tumor like conditions. Results: In our study, the common age groups affected were between 40-60years. Both sexes were equally affected. Most common symptoms were pain and swelling. Knee was the commonest joint involved. Most common histopathological diagnosis made among the clinically suspected synovial lesions was chronic nonspecific synovitis followed by rheumatoid arthritis, septic arthritis& tuberculous synovitis. Also cases of benign tumors including synovial lipoma arborescence, chondromatosis, pigmented villonodular synovitis and malignant tumors like synovial sarcoma and clear cell sarcoma were noted in present study. Conclusion: Histological analysis of synovial biopsies proves to be a valuable tool in establishing an early and specific diagnosis.
Authors and Affiliations
Maithili Mandar Kulkarni, Siddhi Gaurish Sinai Khandeparkar, Avinash R. Joshi, Sukhada R. Patil, Pranoti V. Lengare
Keywords
Related Articles
- EP ID EP318077
- DOI 10.18231/2394-6792.2017.0128
- Views 56
- Downloads 0
Efficacy of cell block immunocytochemistry in the diagnostic workup of non hodgkin lymphoma-experience from a tertiary care hospital in North India
The WHO 2016 update on lymphoid neoplasms incorporates criteria independent of tissue architecture in the diagnosis and subclassification of nonHodgkin lymphoma Thus lymphoid neoplasms with characteristic immunophenotype...
Myxoid Neurothekeoma: Report of a rare tumour at unusual site
Introduction: Neurothekeoma is a rare benign soft tissue tumor of uncertain histogenesis which affects adolescents and young adults. It is rare to find these tumors occurring in children. Neurothekeoma usually presents w...
Malignant pleural effusions with unknown primary sites: A 6 years cytological study
Introduction Malignant pleural effusion is an important complication found in patients of advanced cancers and lead on to exudative effusions Not much data is available regarding malignant pleural effusions with unknown...
Histopathological study of neoplastic lesions of large intestine –A five year experience
Introduction Large intestine has a varied spectrum of lesions both nonneoplastic and neoplastic We took both a retrospective and prospective study in the Post Graduate Department of Pathology The clinical details were so...
Seroprevalence of hepatitis E virus among blood donors in tertiary care center of north Gujarat
Introduction HepatitisE virus HEV is a RNA virus having single strand and spread mainly through contaminated water and food as well as through parenteral route Very few study has been carried out in India in general publ...