CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study
Journal Title: TecnoLógicas - Year 2017, Vol 20, Issue 40
Abstract
Exposure to air pollutants like carbon monoxide (CO), lead (Pb++) and sulfur dioxide (SO2) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb++and SO2block L-type calcium channels, reducing the calcium current (ICaL) and the action potential duration (APD), which favors the initiation of atrial arrhythmias. The goal is to study the effects of CO, Pb++and SO2at different concentrations on ICaLand action potential using computational simulation. For this purpose, models of the effects of the air pollutants on the atrial L-type calcium channel were developed and were incorporatedinto a mathematical model of a human atrial cell. The results suggest thatCO, Pb++and SO2block the ICaLcurrent in a fraction that increases along with the concentration, generating an APD shortening. These results are consistent with experimental studies. The combined effect of the three air pollutants produced an APD shortening, which is considered to be a pro-arrhythmic effect.
Authors and Affiliations
Diana C. Pachajoa, Catalina Tobón, Juan P. Ugarte, Javier Saiz
Keywords
Related Articles
- EP ID EP346390
- DOI 10.22430/22565337.718
- Views 93
- Downloads 0
A mobile app to issue warning for food and nutrition security
This document presents the mobile application EVANI, as a solution to support communities, which allows them in their territories, the identification of cases of malnutrition in children under 60 months of age, as well a...
Design, construction and characterization of pneumatic system for measurement of roughness
This article aims to present the results obtained from the design, construction and characterization of a pneumatic flapper-nozzle amplifier, employed in the measurement of average surface roughness. In the construction...
Classification of Hass avocado (persea americana mill) in terms of its ripening via hyperspectral images
The use of non-invasive and low-cost methodologies allows the monitoring of fruit ripening and quality control, without affecting the product under study. In particular, the Hass avocado is of high importance for the agr...
Evaluation of a statistical model for estimating the solar radiation in Magdalena, Colombia
The global solar radiation is an important meteorological parameter for understanding the biochemical processes in the environment. Their measurement is complex and requires a high cost of installation, operation and mai...
Microfabrication of position reference patterns onto glass microscope slides for high-accurate analysis of dynamic cellular events
Los portaobjetos de microscopio se utilizan ampliamente como sustratos base in situ para larealización de diversos sistemas o elementos microfabricados. Para estos fines, el proceso de microfabricación consiste en trans...