CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study
Journal Title: TecnoLógicas - Year 2017, Vol 20, Issue 40
Abstract
Exposure to air pollutants like carbon monoxide (CO), lead (Pb++) and sulfur dioxide (SO2) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb++and SO2block L-type calcium channels, reducing the calcium current (ICaL) and the action potential duration (APD), which favors the initiation of atrial arrhythmias. The goal is to study the effects of CO, Pb++and SO2at different concentrations on ICaLand action potential using computational simulation. For this purpose, models of the effects of the air pollutants on the atrial L-type calcium channel were developed and were incorporatedinto a mathematical model of a human atrial cell. The results suggest thatCO, Pb++and SO2block the ICaLcurrent in a fraction that increases along with the concentration, generating an APD shortening. These results are consistent with experimental studies. The combined effect of the three air pollutants produced an APD shortening, which is considered to be a pro-arrhythmic effect.
Authors and Affiliations
Diana C. Pachajoa, Catalina Tobón, Juan P. Ugarte, Javier Saiz
Keywords
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