Combination of tranexamic acid and dexmedetomidine reduces postoperative blood loss in patients undergoing bilateral total knee replacement - A randomized controlled study
Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 7, Issue 1
Abstract
Background: Total knee replacement in adults is associated with significant blood loss, often requiring allogenic blood transfusion. Tranexamic acid (TEA) reduces blood loss and red cell transfusions in patients undergoing unilateral total knee arthroplasty (TKA). However, literature is scare regarding the use of combination of tranexamic acid and dexmedetomidine and its effects on post operative blood loss in patients undergoing bilateral TKR in a single stage procedure. With this background this randomized study was taken up to evaluate the combination of tranexamic acid and dexmedetomidine in reducing the postoperative blood loss in elective bilateral total knee replacement. Material and Methods: One hundred and thirty four adult patients with ASA 1 to ASA3 were randomly allocated to 1 of 2 groups using a computer-generated random number table with 67 patients in each group. Group I patients (TAS) received tranexamic acid in a dose of 10 mg/kg and saline in a total volume of 10 mL. Group II (TAD) received tranexamin acid and dexmetomidine 0.5 μg/kg making up the volume to 10 mL. Results: The average blood loss assessed by means of the drain output in the TAD group was significantly lower than the TAS group (376 ml in TAD group vs 710 ml while in the TAS group). The requirement of blood transfusion in the TAD group was significantly lower compared to the group receiving TAS (3.7 units in TAS group vs 2.7 units in TAD group). Conclusion: The combination of Tranexamic acid and dexmedetomidine is effective in reducing total blood loss following bilateral total knee replacement surgery and its efficacy is better when compared to the traditional use of tranexamic acid alone.
Authors and Affiliations
Koramutla Pradeep Kumar, J Subhashree, Chittaranjan Sahu, G Jagadesh
Keywords
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