Comparative assessment of side effects of etomidate and propofol: A double blinded study from urban Karnataka
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 2
Abstract
Background: Propofol and Etomidate is commonly used in anaesthesia practice. However pain on injection and myoclonus are the most common side effects of this drug. Objectives: To compare the side effects between Etomidate and Propofol. Methodology: In this prospective randomized double blinded study, we studied 60 patients randomly allocated into either group P (propofol group) or to group E (Etomidate group) of 30 each. All patients premedicated with inj. midazolam 0.02mg/kg IV, inj. Fentanyl 2 microgm/kg IV. Group P received propofol infusion at 0.5 mg/kg/hr and group E at 0.05mg/kg/hr until BIS value dropped to 50. Then patients were intubated with vecuronium 0.1mg/kg and anaesthesia maintained according to institutional protocol followed by extubation after adequate recovery. Hemodynamic parameters and side effects during induction were recorded between both groups until the infusion of study drug. Results: So prevalence of myoclonus was found to be 40% in Etomidate group. Prevalence of Thrombophlebitis in etomidate was found to be 13.3%. Proportion of patients experienced pain was more in Propofol group i.e. 36.7% as compared to Etomidate i.e. 20%. (>0.05). 10 patients in Etomidate group experienced nausea i.e. 33.3% as compared to 2 in Propofol group i.e. 6.7%. (<0.05). 3 patients in Etomidate group experienced vomiting i.e. 10% as compared to 1 in Propofol group i.e. 3.3% (>0.05) Conclusion: Myoclonus and Thrombophlebitis was observed in Etomidate group only (<0.05). Propofol causes more pain as compared to Etomidate (>0.05). Propofol causes less nausea (<0.05) and vomiting (<0.05) as compared to Etomidate.
Authors and Affiliations
Ramesh babu, Mohan . , Prashanth Vadigeri, Sunil Kumar, Rajashekar Mudaraddi
Keywords
Related Articles
- EP ID EP521033
- DOI 10.26611/10159210
- Views 187
- Downloads 0
A comparative study of dexmedetomidine versus lignocaine used for laryngoscopy and endotracheal intubation with respect to heart rate at tertiary health care centre
Background: Direct laryngoscopy and endotracheal intubation following induction of anesthesia is almost always associated with hemodynamic changes due to reflex sympathetic discharge. This increased sympatho adrenal acti...
A comparative study of combination of dexmedetomidine and midazolam versus combination of midazolam and fentanyl for modified radical mastoidectomy under monitored anaesthesia care
Background: Monitored anaesthesia care (MAC) has gained importance in anaesthesia for both diagnostic and therapeutic procedures in view of providing safe sedation, controlling patient’s anxiety and pain control. MAC typ...
Comparative study between topical nitroglycerine and intravenous lignocaine during laryngoscopy for attenuation of pressor response
Aim: The study was designed to find out pressor response during laryngoscopy and endotracheal intubation with or without pre-treatment of 2% topical nitroglycerine and intravenous lignocaine respectively. Method:150 norm...
A randomized, prospective, comparative study to evaluate the motor blockade properties of 3ml of 0.5% isobaric levobupivacaine and 3ml of 0.5% isobaric ropivacaine for spinal anaesthesia in patients undergoing elective lower limb orthopaedic surgeries
Background: Levobupivacaine is S (-) enantiomer of bupivacaine. It is somewhat less cardiotoxic than the racemic bupivacaine. It seems to be an attractive alternative to Bupivacaine. Ropivacaine is a long acting regional...
Comparison of anaesthetic efficacy of nalbuphine and dexmedetomidine as an adjuvant to ropivacaine and lignocaine in supraclavicular block for upper limb surgeries
Background: Brachial plexus block provides an useful alternative to general anaesthesia for upper limb surgeries. The block characteristics of dexmedetomidine and nalbuphine as adjuvants to ropivacaine, a newly emerging...