Comparative study between topical nitroglycerine and intravenous lignocaine during laryngoscopy for attenuation of pressor response
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 3
Abstract
Aim: The study was designed to find out pressor response during laryngoscopy and endotracheal intubation with or without pre-treatment of 2% topical nitroglycerine and intravenous lignocaine respectively. Method:150 normotensive patients with American Society of Anaesthesiology physical status I and II of both gender posted for surgery under general anaesthesia were divided into three groups of 50 each randomly i.e. control group, intravenous lignocaine group 1.5mg/kg(group I), 2% topical nitroglycerine, 5cm on forehead (group II) respectively. Results: incidence of increase in heart rate was seen in all three groups, at all stages of laryngoscopy and intubation. In group 1 increase of heart rate was 3.17% more than baseline as compared to group II where heart rate increased by 26.6% from baseline after 3 minutes of intubation. In case of blood pressure, it was seen that after induction with inj.1% propofol (2-3mg/kg), there was slight decrease in blood pressure from baseline in all three groups. But after 1 minute of laryngoscopy and endotracheal intubation increase in blood pressure was seen in all groups with maximum increase in control group. After 3 minutes of laryngoscopy and intubation, significant drop in blood pressure was sighted with maximum fall in group II by 10.7% from baseline as compared to group I with 2.28% fall. Conclusion: It can be concluded that either intravenous lignocaine(1.5mg/kg) or 2% topical nitroglycerine can be used to attenuate the pressor response during laryngoscopy and endotracheal intubation. 2% topical nitroglycerine is better choice where better control of blood pressure is required and where slight increase in heart rate is not a matter of concern, and is safe, inexpensive, easily available and easy to apply. Intravenous lignocaine is better choice when both heart rate and blood pressure have to be controlled but control of blood pressure is always lesser than topical nitroglycerine.
Authors and Affiliations
Sandip Baheti, Mrininayee Sathe, Maya Jamkar, Usha Padhye, Shivangi Gaur, Kaushik Cherukuri
Keywords
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- EP ID EP521595
- DOI 10.26611/10159320
- Views 155
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