Comparative in-vitro release profile of formulated microparticles containing indomethacin using synthetic and natural polymer (Gum Karaya)
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 7
Abstract
The ability to deliver drugs to the target site is feasible over the years. In the present study, microspheres of Indomethacin (IM), which is a non steroidal anti inflammatory drug (NSAIDs) employing Gum karaya (GK) as the hydrophilic carrier, prepared by emulsion solvent evaporation technique which will provide prolong the release. Gum karaya is dried gummy exudates obtained from the tree Sterculia urens (Roxburgh). Microspheres containing Indomethacin (IM) were prepared by emulsion solvent evaporation method by using hydroxypropyl methyl cellulose (HPMC) and Gum karaya (GK) as rate controlling polymer. The prepared microspheres were characterized by particle size, percentage yield, entrapment efficiency, micromaritic properties, in-vitro release behavior, scanning electron microscopy (SEM), FTIR etc. The in-vitro release studies was performed by buffer change method to mimic Gas Intestine Tract (GIT) environment in 0.1 N HCL, carbonate buffer (acidic) and pH 7.4, phosphate buffer (Alkaline). The prepared microspheres were pale yellow, free flowing and spherical in shape. The mean particle size of the microspheres was found in the range of 289 to 384 μm. The drug-loaded microspheres show high entrapment efficiency (72.4%) and release was extended up to 6 to 8 hours releasing 90% of the total drug from the microspheres. The infrared spectra showed stable character of Indomethacin in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. It was concluded that the gum possess substantial release controlling properties that could be used for sustained drug delivery.
Authors and Affiliations
Girraj Tyagi1*, Jyotirmoy Deb1, Amitava Ghose1, Amitav Roy1, Braj Kishor Tiwari1, Radha Raman Tiwari1, Faizi Muzaffar2
Keywords
Related Articles
- EP ID EP86354
- DOI -
- Views 160
- Downloads 0
Anticonvulsant activity of Artemisia nilagirica leaves
Ob j e c t i v e : The aim of the present study was to evaluate the anticonvulsant activity and neurotoxicity of methanol extract of Artemisia nilagirica leaf and its ethyl acetate fraction in mice. Methods: The anticon...
A Selective Reverse Phase HPLC Method For Simultaneous Determination of Perindopril and Indapamide In Solid Dosage Form And Bulk Drug
A rapid and accurate reverse phase high performance liquid chromatographic method has been developed, validated and used for the quantitative determination of Perindopril and Indapamide, from solid dosage forms and bulk...
Phytochemical analysis and Antimicrobial activities of different plant parts of Vitex negundo L
In the present work leaf and bark extracts of V. negundo were screened for antibacterial and anticandidal property. Qualitative phytochemical analysis, agar cup method, micro-dilution method for MIC, TLC bioautography w...
The Antiulcer Activity of Aerial parts of Jatropa curcas.
The anti-ulcer activity of methanolic extract of Jatropa curcas (Euphorbiaceae) aerial parts was investigated in pylorus ligation and Indomethacin induced ulcer models in wistar rats. In both models the common parameter...
Comparative In vitro screening of a-Amylase and a-Glucosidase enzyme Inhibitory studies in leaves of Annona species
Diabetes is a syndrome of disordered metabolism resulting in abnormally high blood sugar levels (hyperglycemia). The one possibility of lowering postprandial glucose levels is by the inhibition of a-amylase and a-glucos...