COMPARATIVE LC-MS STABILITY INDICATIND ASSAYS OF ONDANSETRON HYDROCHLORIDE/NALOXONE HYDROCHLORIDE AND METOCLOPRAMIDE HYDROCHLORIDE/NALOXONE HYDROCHLORIDE USED IN PALLIATIVE CARE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objectives: To compare the compatibility and chemical stability of ondansetron hydrochloride/naloxone hydrochloride and metoclopramide hydrochloride/naloxone hydrochloride admixtures used in palliative care units at three different storage conditions (4ËšC, 22 ËšC and 37ËšC) for 192 hours.Methods: A high performance liquid chromatography-mass spectrometry (LC-MS) analytical method was established to investigate the chemical stability of the combinations.Results: Metoclopramide hydrochloride and naloxone hydrochloride concentrations remain above 90% of their initial concentration under all storage conditions for 192 hours, while ondansetron hydrochloride remain stable at 4ËšC and 22ËšC but it losses up to 15.03% of its initial concentration when stored for 192 hours at 37 ËšC.Conclusion: metoclopramide hydrochloride and naloxone hydrochloride admixture is more stable and preferred to ondansetron hydrochloride and naloxone hydrochloride admixture under all storage conditions.Â
Authors and Affiliations
Naser F Altannak
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