COMPARATIVE STUDY OF EFFECT OF SWERTIA CHIRATA LEAF EXTRACT ON INDINAVIR TREATED RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 2
Abstract
Background: Indinavir is widely used for the treatment of human immunodeficiency virus (HIV) infection. It is known to cause hyperglycemia or insulin resistance and hyperlipidemia.Aim and Objectives: To study the effect of Swertia chirata leaf extract with metformin and pioglitazone on indinavir treated rats.Methods: Swiss albino rats were divided into five Groups of six animals each. All the groups (except control) were treated with indinavir 216 mg/kg (oral) for 15 days. Group I (control) received normal saline (oral) from day 8 to day 15, Group II received indinavir 216 mg/kg (oral), Group III received S. chirata plant extract 500 mg/kg (oral) from day 8 to day 15, Group IV received pioglitazone 4 mg/kg (oral) from day 8 to day 15, and Group V received metformin 36 mg/kg (oral) from day 8 to day 15. The biochemical parameters such as serum glucose, insulin, and lipid levels were measured on day 15. Results were analyzed using one-way analysis of variance followed by Bonferroni’s multiple comparison test.Results: Indinavir (216 mg/kg) treated rats showed a significant (p<0.05) increase in glucose and insulin levels and also altered lipid levels. This indicates indinavir produces diabetic-like state in rats. S. chirata extract (500 mg/kg) decreases glucose and insulin levels and also improves lipid levels the effect is almost similar to metformin and pioglitazone.Conclusion: Indinavir causes elevated glucose, insulin and lipid levels, so care must be taken while prescribing indinavir for HIV patients. Treatment with S. chirata extract improved the altered glucose, insulin, and lipid profile in indinavir treated rats.Key words: Indinavir, Insulin resistance, Diabetes dyslipidemia, Glucose intolerance.
Authors and Affiliations
Chigatanahalla Subramanya Rajesh
Keywords
Related Articles
- EP ID EP605465
- DOI 10.22159/ajpcr.2017.v10i2.15723
- Views 87
- Downloads 0
ACACIA SENEGAL BARK EXTRACT IN REGULATION OF HYPOTHYROIDISM: AN EXPERIMENTAL APPROACH
Objective: The objective of the present study was to evaluate the thyroid hormone stimulating efficacy of Acacia senegal (Gum Arabic) bark extract in 6-n-propyl-2-thiouracil (PTU)-induced hypothyroid albino rats.Methods:...
COUGH AND CHEST PAIN WITH AN UNCOMMON CAUSE
Multiple Hereditary  Exostoses is an autosomal dominant disorder with multiple cartilage capped bony outgrowths in tibia ,fibula, femur, and sometimes the ribs and scapula. They...
FUSOGENIC LIPOSOME FOR THE TREATMENT OF FUNGAL MENINGITIS: AN OVERVIEW
Fungal meningitis is an infection which is caused by fungus which spreads through the blood to the spinal cord. People with weakened immunity get this disease easily like persons with AIDs, etc. To make sure the disease...
CREATION, PHYSICAL AND CHEMICAL PROPERTIES OF ALKIL-2-((5-PHENETHYL-4-R-1,2,4- TRIAZOLE-3-YL)THIO)ACET(PROPAN,BENZ)IMIDATES
Objective: The aim of this research was to synthesize and evaluate physical-chemical properties of 5-pheneyhyl-4-R-3-thio-1,2,4-triazole and to establish identity and structure of the synthesized compounds, namely alkil-...
ANALYSIS AND RESULTS: CONFIRMATORY FACTOR ANALYSIS THE MALAY VERSION OF DREEM INVENTORY WITH MEDICAL STUDENTS OF UNISZA, KUALA TERENGGANU, MALAYSIA
  Objectives: The DREEM inventory has been universally established as a generic instrument to assess health-related educational programs. There were some apprehensions regarding the psychometric properties of the DREEM...