COMPARATIVE STUDY OF ORAL L-ARGININE THERAPY VERSUS NON-AMBULATORY TREATMENT IN PREGNANCY WITH ASYMMETRICAL FETAL GROWTH RESTRICTION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 6
Abstract
L-arginine is a unique molecule that produces nitric oxide in body and plays a crucial role in physiological hemodynamic modification in pregnancy. A randomised comparative prospective study was carried out in a maternity hospital in Kolkata over one year. The study involved a study group of fifty antenatal mothers with asymmetrical fetal growth restriction detected ultrasonographically around 30-32 weeks of gestation and treated with 5 grams of L-arginine per day over a period of 28 days and a historical control group of fifty patients of same parameters with non- ambulatory treatment in home atmosphere. The aim of our study was to compare the fetal growth and pregnancy outcomes in pregnant mothers supplemented with L-arginine with that in the control group with non-ambulatory treatment in home atmosphere. L-arginine was found to accelerate fetal growth. Fetal growth restriction at delivery in L-arginine group was 42% compared to 46% in control group (p=0.84). Moreover, neonates of treatment group revealed higher Apgar score, lower incidence of respiratory distress syndrome (16% versus 42%, p=0.0076) and intraventricular haemorrhage (2% versus 20%, p=0.007) and lower admission to neonatal intensive care unit (10% versus 44%, p=0.000225). Caesarean section rate was higher in control group than in arginine group (80% versus 72%, p=0.48). Hence, oral treatment with L-arginine seemed promising in improving fetal outcome.
Authors and Affiliations
Ananda Mondal , Jayati Mondal , Rudrajit Paul
Keywords
Related Articles
- EP ID EP148178
- DOI 10.7897/2230-8407.06676
- Views 126
- Downloads 0
EVALUATION OF ANTIBACTERIAL ACTIVITY OF STUDY OF LEAVES OF TABERNAEMONTANA DIVARICATA (L)
Phytochemical analysis of the dried leaves of Tabernaemontana divaricata (L). (Apocynaceae) indicated the presence of a steroids,tannins, saponins, gums and reducing sugar. The pharmacological interest of these compounds...
AMOMUM SUBULATUM ROXB: AN OVERVIEW IN ALL ASPECTS
Amomum subulatum Roxb. (Family Zingiberaceae) is commonly known as ‘Badi Elaichi’ or Greater Cardamom. The present study deals with the an overview in all aspects of Amomum subulatum Roxb. It contain Protein 6.0%, Starch...
NOVEL 3-ACETYLCOUMARIN SCHIFF’S BASE SYNTHESIS FROM DIFFERENT ACID HYDRAZIDE
A new series of Schiff’s bases, SB1, SB2 and SB3 were synthesized from 3-acetylcoumarin and different acid hydrazides. The 3-acetyl coumarin was synthesized starting from salicylaldehyde and ethylacetoacetate. The struct...
EAT AN ORANGE TO KEEP ANXIETY AT LONG RANGE
Orange fruit (citrus sinensis) is a favorite fruit of all sections of the society, particularly among patients suffering from different ailments for its nutritional and medicinal properties. This study was undertaken to...
ANTIMICROBIAL ACTIVITY OF BIOSYNTHESIZED SILVER NANOPARTICLES PREPARED FROM THE LEAF EXTRACT OF LANTANA CAMARA
Lantana camara commonly known as weed or red sage is found throughout India. It was reported to be used in traditional medicine system for infectious diseases. The present study designed to evaluate antimicrobial activit...