Comparative study of succinylcholine and precurarization with rocuronium on muscular effects in patients undergoing surgery under general anaesthesia
Journal Title: Pakistan Journal of Pharmacology - Year 2011, Vol 28, Issue 1
Abstract
Succinylcholine remains the drug of choice in conditions where rapid paralysis and airway control are priorities. However it is associated with muscular side effects that have an overall incidence ranging from five to 83 percent. The administration of small doses of nondepolarizing muscle relaxants before the administration of succinylcholine has been shown to decrease the incidence and severity of muscular side effects experienced by the patients. This study was aimed at evaluating the efficacy of technique in reducing the muscular side effects of succinylcholine. Sixty healthy adults were enrolled in the study who were scheduled for minor muscle cutting surgeries under general anaesthesia. They were assigned at random to two groups of thirty patients each. They randomly received succinylcholine for intubation and a precurarization dose of rocuronium followed by succinylcholine for intubation. Intraoperative fasciculations and postoperative myalgia were graded and scored. There was a significantly increased incidence of fasciculations and myalgia in the succinylcholine group. In the precurarization group the incidence and severity of fasciculations and myalgia was significantly less as compared to the group which received succinylcholine alone. We found significant correlation between fasciculations and myalgia in the succinylcholine group. Present study concluded that precurarization with rocuronium was effective in reducing the succinylcholine-induced fasciculations and myalgia.
Authors and Affiliations
Kulsoom Farhat, Akbar Waheed, Salman Bakhtiar , Anwar Pasha
Keywords
Related Articles
- EP ID EP93171
- DOI -
- Views 179
- Downloads 0
Implication of age and gender on cardio toxicity in patients treated with two schedules of 5FU/LV
Cardio toxicity induced by chemotherapeutic agents can interfere with the cumulative therapeutic benefit and debilitate the elderly with a comorbid burden. The cardio toxic potential of 5-FU based chemotherapy is known,...
Moxifloxacin in the treatment of uncomplicated enteric fever
Many drugs have been used for the treatment of enteric fever. Moxifloxacin is a newer fluoroquinolone antibiotic also said to be effective against Salmonella typhi. In order to evaluate its effectiveness in our populati...
To study the efficacy and safety of combination treatment using allopurinol and fenofibrate in patients with hyperuricemia
Allopurinol is the most frequently used antihyperuricemic drug. Fenofibrate, a derivative of fibric acid, is commonly used in the treatment of hyperlipidemia. Fenofibrate treatment has been shown to decrease serum urate...
Interferon (IFN a) induced depression in patients of hepatitis C (HCV)
HCV is a global problem and the worst affected are the 3rd world countries. In our study of 802 patients 244 male and 161 females were positive for HCV. Majority of the patients were in age group 26-40 Years i-e 56.04% o...
Determination of neuron specific enolase (NSE) in small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) patients
Neuron specific enolase (NSE) is routinely used as tumor marker in Small cell lung carcinoma (SCLC), and to some extent in non-small cell lung carcinoma (NSCLC). In Pakistan, tumor marker technology is not a new one. It...