Comparison of analgesic efficacy of two different preparations of intravenous paracetamol for day care surgeries
Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 7, Issue 2
Abstract
Background: Paracetamol is a non- opioid analgesic drug which is widely used for treatment of pain and fever .Intravenous paracetamol (with excipients) given as infusion provide analgesia by the end of 15 minute infusion. Its relative high cost is one of the limiting factors. Inj Paracetamol available in ampoule (without excipients) can be suitably diluted and given as infusion. Its cost is comparatively less than ready to use infusion preparation. In this study we have compared postoperative analgesic efficacy of both preparations of paracetamol. Methodology: Patients in the age group 18 to 60 yrs ASA grade I and II of both sex for day care surgeries receiving general anesthesia were studied. One group of 40 patients received 15mg/kg of Inj. Paracetamol infusion (with excipients) 30 minute before induction and another group of 40 patients received 15mg/kg of Inj. Paracetamol infusion from ampoule diluted in 100 ml normal saline (without excipients) 30 minutes before induction in premedication room. Intraoperative hemodynamic rameters were recorded. Pain level was assessed by Visual Analog Scale at postoperative 30, 60, 90 and 120 minutes. Result: The patient characteristics, demographic data and surgical procedures were comparable in the two groups. VAS score in postoperative period in both groups of patients were comparable. Conclusion: Paracetamol infusion prepared from ampoule (without excipients) provides comparable and cost effective postoperative analgesia as with aracetamol 100 ml infusion (with excipients).
Authors and Affiliations
Leena Shibu, Anita Kulkarni, Shilpa Gurav
Keywords
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