Comparison of effect of Labetalol and fentanyl with only fentanyl for attenuating pressure responses to intubation and skull pin insertion in neurosurgery
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 2
Abstract
Introduction Laryngoscopy and intubation as well as application of skull pin in neurosurgical procedure is a highly noxious stimulus which causes hemodynamic changes and can be detrimental in patients with raised intracranial pressure We studied the effect of addition of intravenous labetalol with fentanyl to attenuate the pressure response to intubation and skull pin insertion in neurosurgeryMaterials and Methods Fifty patients undergoing elective neurosurgical procedure were randomised into two groups as group LF and group F Patients of group LF received intravenous Labetalol 025mgkg 5 minutes prior and intravenous fentanyl 2gkg 3 minutes prior to intubation Patients of group F received intravenous saline 5 minutes prior and intravenous Fentanyl 2gkg 3 minutes prior to intubation Heart rate HR systolic and diastolic blood pressure SBP and DBP and mean arterial pressure MAP were noted at baseline after study drug administration after induction immediately after intubation immediately after skull pin insertion 5 minutes interval till 20 minutes after thatResults Immediately after intubation HR was 826050 per minute in LF group and 9764 471 per minute in group F p001 MAP was higher in group F than group LF 10684389 mm of Hg 8302375 mm of Hg respectively p0001 Immediately after skull pin insertion rise in HR group LF 7976507 per minute group F 9784440 per minute respectively p0001 and MAP group LF 8028532 mm of Hg group F 10317766 mm of Hg respectively p0001 was at lesser extent in group LFConclusion Addition of single dose intravenous labetalol to fentanyl gives better haemodynamic stability to laryngoscopy and intubation as well as skull pin insertion than fentanyl aloneKeywords Skull pins Labetalol fentanyl Hemodynamic changes Pressure response
Authors and Affiliations
Leena P. Patel, Jenish C. Patel, Keval P. Patel, Chirag S. Rathva, Vijeta Tandel
Keywords
Related Articles
- EP ID EP476450
- DOI 10.18231/2394-4994.2018.0037
- Views 73
- Downloads 0
Intraoperative requirement of Phenylephrine for spinal anaesthesia, with comparison of hemodynamic parameters between severe pre-eclamptic and normotensive parturients for elective caesarean section: A prospective study
Aim: The aim of this study is to assess the efficacy and safety of spinal anaesthesia by comparing the severity of hypotension and intraoperative requirement of Phenylephrine to treat it in severe pre-eclamptic and normo...
Comparison of two supraglottic airways - I-gel and Proseal laryngeal mask airway for ease of insertion and hemodynamic stability
Introduction and Aims: Supraglottic airway devices are safe and efficient in airway management. I-gelTM and ProsealTM laryngeal mask airway are supraglottic airway devices which are used to secure and maintain airway dur...
A randomized clinical trial to compare the effectiveness of two different doses of intravenous Nitroglycerine for manual removal of placenta
Introduction After the birth of the baby if the placenta is not expulsed within 30 minutes of the delivery it is termed as retained placenta The incidence of retained placenta is 2 of deliveries worldwide and is an impor...
A study of effectiveness of 0.5% bupivacaine for sensory blockade as local anesthesia in epidural and spinal phase
Background: Bupivacaine is a long-acting local anesthetic. Addition of epinephrine is thus rarely required. It blocks initiation and transmission of nerve impulses at the site of application by stabilizing the neuronal m...
Evaluation and comparison of intravenous clonidine and intravenous dexmedetomidine on duration of bupivacaine spinal anesthesia
Context: Alpha-2 agonists improve the block characteristics in regional anesthesia, when added to local anesthetics. Aim: To evaluate and compare efficacy of dexmedetomidine and clonidine, as an intravenous adjuvant to i...