COMPARISON OF MEASUREMENT OF DIRECT LDL-C Vs CALCULATED LDL-C
Journal Title: Stanley Medical Journal - Year 2016, Vol 3, Issue 4
Abstract
Context: Serum LDL-C is an independent & modifiable risk factor for coronary heart disease and it is the major criterion for diagnosis and treatment of patients with Hyperlipidemia. Aims: To calculate LDL-C by Friedewald’s formula and compare Calculated LDL-C values with the direct LDL-C measurement by Enzymatic Colorimetric assays to study the need for direct Homogenous assays for LDL-C estimation. Settings and Design: This Analytical study was conducted in patients coming to the OPD in Stanley Medical College Hospital. Methods and Material: LDL-C was determined by Enzymatic Colorimetric assays and Friedewalde’s Formula in blood samples collected randomly from 130 fasting patients coming to the OPD. Statistical analysis used: Chi-square test, Regression analysis and Bland-Altman plot applied with the help of Microsoft Excel Software for comparing Calculated and direct LDL-C values. Results: Statistical analysis suggests that the reliability of Calculated LDL-C estimation decreases considerably with increase in the TAG levels Conclusions:With TAG levels >400mg/dl, Cholesterol is overestimated by Friedewald’s calculation resulting in underestimated LDL-C values and therefore the need for direct method comes in clinical application.
Authors and Affiliations
Siva Somana. J, Mahalakshmi R, Vijayalakshmi M
Keywords
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