Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 2
Abstract
The online version of this article (doi:10.1208/s12248-012-9336-7) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Caroline Watson, Joshua S. Sharp
Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints
Pre-clinical behavioral pharmacology studies supporting indications like analgesia typically consist of at least three different studies; dose-finding, duration of effect, and tolerance-development studies. Pharmacokinet...
Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging
Magnetic iron oxide nanoparticles (MNP) coated with gum arabic (GA), a biocompatible phytochemical glycoprotein widely used in the food industry, were successfully synthesized and characterized. GA-coated MNP (GA-MNP) di...
Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant
Proton-coupled oligopeptide transporter PEPT1 facilitates the transport of dipeptides and peptoid drugs (including antibiotics) across the cell membranes of endothelial and epithelial cells. Substrate transport by the pr...
Development of a Novel Oral Cavity Compartmental Absorption and Transit Model for Sublingual Administration: Illustration with Zolpidem
The online version of this article (doi:10.1208/s12248-015-9727-7) contains supplementary material, which is available to authorized users.
Inactivation of hepatic enzymes by inhalant nitrite—In vivo and in vitro studies
We examined the effects of acute isobutyl nitrite (ISBN) exposure on the activity of several hepatic enzymes. Two strains of adult male mice (Balb/c and C57BL/6) were exposed to 900 ppm ISBN or ambient air for 45 minutes...