Correlation between Immunohistochemical Caveolin -1 Expression and Clinicopathological Parametres in Gastric Adenocarcinomas
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 2
Abstract
Objective: Caveolin- 1 protein encoded by CAV1 gene regulates many different biological processes including carcinogenesis. Its correlation with prognosis in various tissue malignancies has been indicated in many investigations. The objective of this study is to evaluate the relationship between immunohistochemical caveolin-1 expressions with other clinicopathological parameters. Material and Method: All clinical information about 116 cases with gastric carcinoma who had been undergone gastrectomy between 2011, and 2014 were reviewed. Caveolin-1 expression was evaluated using immunohistochemical methods. Results: As is the case with normal tissues, tumors with limited caveolin-1 expression observed in the perivascular area were accepted as caveolin-1 negative tumors. Caveolin-1 expression was of stromal or tumoral pattern in 58 cases. In Kaplan- Meier survival analysis caveolin-1 expressing cases had lower survival rates (p=0.04). Conclusion: Contribution of tumoral caveolin-1 expression to tumor aggressiveness, and contrarily antitumoral activity of stromal caveolin-1 expression have been reported in many studies. In compliance with literature findings, our study results suggested adverse prognostic impact of caveolin-1 expression in gastric carcinomas However since tumoral caveolin-1 expression was detected in only 5 cases, cases expressing tumoral or stromal caveolin-1 could not be subjected to intragroup comparisons. Therefore these findings should be confirmed in larger case series.
Authors and Affiliations
Gulden Diniz
Keywords
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