Correlation between Low Grade Inflammation with Endothelial Progenitor Cells Surface (EPCs) Marker in Hypertension
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2012, Vol 1, Issue 1
Abstract
Patients with hypertension have been shown to express reduced number and functional capacity of endothelial progenitor cells (EPCs). Recent study reveals that EPCs contain an important capability to maintain endothelial integrity and vascular homeostasis. Therefore, enhancement of EPCs could be benefit for individuals with cardiovascular diseases. We investigated the correlation between low grade inflammation marker (hsCRP) with EPC surface marker (CD34 total) in hypertension. This was an observational study with cross sectional design conducted in 51 nonhypertenive and 60 hypertensive subjects. hsCRP (as marker of inflammation) was measured by immunochemiluminometric method. CD34 total (as marker of EPC) was measured by flow cytometry method. hsCRP concentration was higher in hypertensive subjects compare to nonhypertensive subjects (mean±SD, 2.709±2.50 vs 2.476±2.438 mg/L; P>0.05). CD34 total level was lower in hypertensive subjects compare to nonhypertensive subjects (mean±SD, 1.957±0.858 vs 3.244±3.463/μL; P<0.05). hsCRP had positive correlation with CD34 total in hypertensive subjects (P<0.05). The increasing concentration of hsCRP will stimulate the CD34 total level in hypertensive subjects as demonstrated by the positive correlation between hsCRP with CD34 total.
Authors and Affiliations
Johnson Widjaja, Syakib Bakri, Marsetio Donosepoetro
Keywords
Related Articles
- EP ID EP332059
- DOI -
- Views 136
- Downloads 0
Lactobacillus plantarum as Biopreservative Agent in Paneer for Dietary Food of Diabetic and Coronary Heart Disease Patients
Paneer is a food product that is obtained by heating milk followed by acid coagulation. It is known as a diet food that is recommended for diabetic and coronary heart disease patients. A relatively shorter shelf life of...
Enhancing Pharmacist’s Role and Tuberculosis Patient Outcomes Through Training-Education-Monitoring-Adherence-Networking (TEMAN) Pharmacist Model Intervention
Training-Education-Monitoring-Adherence-Networking (TEMAN) Pharmacist model provides opportunities for trained pharmacist to intervene through education of tuberculosis (TB) patient, therapy monitoring, assessment of pat...
Satisfaction’s Level of Hypertensive Patients towards Pharmacy Counseling with Al-Quran Based at Karya Sehat Pharmacy in Purwokerto, Banyumas Regency
Hypertension is a major cause of death in some countries. World Health Organization (WHO) estimated there are 11% of undetected hypertension in which 50% of them are living in developing countries such as Indonesia, wit...
Potential of Drug-Drug Interaction in Polypharmacy Prescription: Retrospective Study on a Drugstore in Bandung
Polypharmacy prescription very commonly occurs on prescribing the outpatient and inpatient in every health facility. Polypharmacy may increase the risk of Drug-drug Interactions (DDI’s) which mostly causes harm impact in...
Quality of Life Evaluation of Respondents with Hypertension Aged 40–75 Years Using SF-36 Instruments in Kalasan District, Sleman, Yogyakarta Province
Hypertension is a condition of an increase of systolic blood pressure over 140 mmHg and diastolic blood pressure over 90 mmHg. Poor health status indicates poor quality of life. There are many factors that may affect the...