CORRELATIONS BETWEEN PRO-INFLAMMATORY MARKERS AND GLYCATED HEMOGLOBIN IN TYPE 2 DIABETES PATIENTS

Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2011, Vol 18, Issue 4

Abstract

Background and Aim. Markers of inflammation are predictive of diabetic macrovascular complications. In type 2 diabetes, inflammation might be responsible for enhancing insulin resistance and may contribute to the reduction of islet cells secretory function. In the present study, we investigated the correlation between the pro-inflammatory markers and glycated hemoglobin in patients with type 2 diabetes mellitus. Materials and Methods. 66 patients (32 women and 34 men) with type 2 diabetes were recruited for this study. On fasting plasma samples C-reactive protein, interleukin-6, tumor necrosis factor-α (TNF-α) and glycated hemoglobin (HbA1c) were assayed. C-reactive protein, interleukin-6 and TNF-α were measured using enzyme-linked immunosorbent assays. The HbA1c were measured using a high-performance liquid chromatography method. Results were compared to the corresponding parameters obtained for 38 subjects (18 women and 20 men) without type 2 diabetes (control group). Results. The groups were similar in terms of age and sex but there were statistically significant differences in the recorded parameters in diabetic patients compared to the control group. Circulating levels of C-reactive protein, interleukin-6, TNF-α and HbA1c were higher (p<0.05) in patients with type 2 diabetes mellitus compared to normally metabolic patients. In the patients with type 2 diabetes mellitus HbA1c were significantly correlated with circulating C-reactive protein (r=0.909, p<0.001) and interleukin-6 (r=0.883, p<0.001) levels. Conclusion. The markers of inflammation are significantly higher in patients with type 2 diabetes compared to subjects without diabetes. The elevated markers of inflammation (C-reactive protein and interleukin-6) were significantly correlated with glycemic control (HbA1c).

Authors and Affiliations

Rucsandra Dănciulescu Miulescu, Denisa Margina, Marlena Pascu, Sorin Paun

Keywords

Related Articles

ANKLE BRACHIAL PRESSURE INDEX, VALUE AND LIMITATIONS CONSIDERATIONS ABOUT ITS APPLICABILITY FOR DIABETIC INDIVIDUALS

Non-invasive ultrasound investigations are frequently used as a screening maneuver for peripheral vascular disease. The ankle to brachial pressure index (ABPI) it is a noninvasive hand-held Doppler test that is able to p...

 PATHOGENESIS OF TYPE 1 DIABETES MELLITUS: A BRIEF OVERVIEW

 Before the discovery of insulin, type 1 diabetes mellitus (DM) was a disease with acute evolution, leading to death shortly after diagnosis. During the first years of insulin therapy, the medical world was optimist...

 THE RELATIONSHIP BETWEEN 1 HOUR GLYCEMIA, DURING ORAL GLUCOSE TOLERANCE TEST AND CARDIOMETABOLIC RISK

 Background Diabetes mellitus is a very common disease, worldwide there are currently over 366 million diabetics. It seems that people with normal glucose tolerance and blood glucose at 1 hour during OGTT ≥200mg% re...

FEEDING BEHAVIOR EVALUATION IN PERSONS WITH NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS IN SALAJ COUNTY

The paper analyzes the behavior and eating habits of people newly diagnosed with type 2 diabetes in Sǎlaj county. As a working method a questionnaire was used to assess the nutrition and eating habits; the sample chosen...

Download PDF file
  • EP ID EP160854
  • DOI -
  • Views 114
  • Downloads 0

How To Cite

Rucsandra Dănciulescu Miulescu, Denisa Margina, Marlena Pascu, Sorin Paun (2011). CORRELATIONS BETWEEN PRO-INFLAMMATORY MARKERS AND GLYCATED HEMOGLOBIN IN TYPE 2 DIABETES PATIENTS. Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 18(4), 287-292. https://europub.co.uk./articles/-A-160854