Could Monocytes Colonized by Circulating Epithelial Cells of the Prostate Gland be a Source of Metastasis of the Adenocarcinoma? A Hypothesis Based on a Previous Study
Journal Title: Journal of Cancer and Tumor International - Year 2016, Vol 4, Issue 2
Abstract
Background: Recently we reported the successful in vitro cultivation of prostatic epithelial and stromal cells from patients with benign prostatic hyperplasia and adenocarcinoma of the prostate by liquid biopsy. In that study we noticed monocytes that were colonized by prostatic epithelial cells; this was confirmed using a monoclonal antibody to prostate epithelial cells. We also detected a deleterious effect exerted on the monocyte cytoplasm by a process yet to be determined. Aim: To develop a hypothesis that will explain the significance of monocytes colonized by prostatic epithelial cells in the pathogenesis of prostate adenocarcinoma. Study Design: Retrospective analysis of images in the previous study. Place and Duration: Kilimanjaro Christian Medical University College, Tumaini University, Moshi, Tanzania. One month. Results: We found that all monocytes viewed, without exception, contained intra-cytoplasmic prostatic epithelial cells and most of them presented with apparent cytopathology. The cytopathology presented as strand formation and shrinkage of monocytes. Often the loss of integrity of monocyte cytoplasm could be arbitrarily graded as little to complete loss of cytoplasm. Conclusion: We hypothesize that epithelial cells invade monocytes and colonize the cytoplasm. Monocytes colonized by epithelial cells then participate in the metastatic process of the prostate adenocarcinoma to different parts of the body. We report for the first time, a monocyte colonized by an epithelial cell of the prostate gland. This could also be an unrecognized phenomenon with other types of cancers.
Authors and Affiliations
Mramba Nyindo, Abdul-Hamid Lukambagire, Lucy Mimano
Keywords
Related Articles
- EP ID EP243337
- DOI 10.9734/JCTI/2016/28227
- Views 92
- Downloads 0
The Implication of the Preoperative Neutrophil to Lymphocyte Ratio in the Diagnosis of Laryngeal Squamous Cell Carcinoma: A Retrospective Analysis
Aims: There is growing evidence that the neutrophil to lymphocyte ratio (NLR) may be used as a prognostic factor in many head and neck cancer types. We aimed to investigate the diagnostic implication of the NLR as a biol...
The Pathological Stage at Diagnosis of Breast Cancer in Ghanaian Women: A Retrospective Study at the Korle-Bu Teaching Hospital Accra (2001 to 2014)
Background: Published data on breast cancer (BC) in Ghanaian women have not look at the relationships between pathological stage at diagnosis and the other clinico-pathological features. The aim of this study was to desc...
Photodynamic Therapy for Vulvar Carcinoma in situ (Case Report)
The article presents a clinical case of the successful application of photodynamic therapy with chlorine e6-based photosensitizer photolon in a patient with vulvar cancer in situ. The use of an exposure dose of light of...
Kolaviron an Active Biflavonoid of Garcinia kola Extract Prevent 1,2-dimethylhydrazine Induced Oxidative Stress and Lipid Peroxidation in the Initiation Phase of Colon Carcinogenesis in Wistar Rats
Colon cancer is steadily increasing in Africa with high mortality and it is a pathological consequence of persistent oxidative stress. Kolaviron an active biflavonoid, has been shown to possess antioxidant, anti-lipid pe...
Histo-Epidemiology of Kidney Cancer in Cameroon: About 110 Cases
Objectives: To describe the epidemiological and histopathological aspects of kidney cancer in Cameroon. Materials and Methods: This was a descriptive retrospective study on malignant tumors of the kidney examined in the...