CURRENT THERAPEUTIC STRATEGY IN DIABETIC NEUROPATHY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Diabetic neuropathy (DN) is a group of multifactorial disorder in diabetic patients, which affects neuronal function of the whole body and is accompanied by nephropathy and angiopathy. Its prevalence increases with duration of diabetes and hyperglycaemia which can induce oxidative stress resulting in activation of multiple pathways which can damage the neurons alone or in combination. Symptoms of DN are prominent early in type 2 than in type 1. Neuropathic pain which can occur continuously only in 20-30% of the patients, otherwise pain was not reported. The drugs available for DN were not able to cure the disease but provide only symptomatic relief and were also associated with major side effects. Current therapy provided in this review alleviates the symptoms in clinical trials and thus will be recommended in order to stop the progression of disease. Despite the recent understanding regarding the pathogenesis of disease, till date only two drugs were approved by FDA for DN, α-lipoic acid is available in several countries and epalrestat in Japan, which is also associated with side effects but they are tolerable.
Authors and Affiliations
Parminder Kaur , A. S Kushwah , Ravinderpal Kaur
Keywords
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