CYCLODEXTRINS: AN EXCIPIENT TOOL IN DRUG DELIVERY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Cyclodextrins (CDs) are a family of compounds consist of glucose monomers arranged in a donut shape ring. They are non-reducing, crystalline cyclic oligosaccharides which proximate a truncated core generating a hydrophilic outer surface and a lipophilic interior cavity that offers interaction with appropriately sized molecules to result in the formation of inclusion complex. Cyclodextrins are able to form host-guest complexes with hydrophobic molecules given the unique nature imparted by their structure. As a result, these molecules have found a number of applications in a wide range of fields. The proposed review explores the various techniques used and advantages for the formation of inclusion complex. The CDs have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their use as complexing agent to increase the aqueous solubility of poor soluble drugs and to increase their bioavailability and stability. The article also highlights extensive use of CDs as a polymer in the design of various novel delivery systems like liposomes, microspheres, nanoparticles that can be expected to improve the therapeutic efficacy of drug and patient compliance. The objective of this contribution is to point out the inherent use of chemically modified cyclodextrins as high performance drug carriers in drug delivery systems with emphasis on the current developments. Thus, CDs because of their continuing ability to find several novel applications in drug delivery are expected to solve many problems associated with the delivery of different novel drugs through different delivery routes.
Authors and Affiliations
Nasir Ali , S. L. Harikumar , Amanpreet Kaur
Keywords
Related Articles
- EP ID EP124881
- DOI -
- Views 83
- Downloads 0
DEVELOPMENT AND VALIDATION OF METHOD FOR DETERMINATION OF CICLESONIDE IN (MICRONIZED) BY HPLC
A simple, selective and rapid reversed phase high performance liquid chromatographic (RPHPLC) method for the analysis of Ciclesonide has been developed and validated. The separation was achieved from HPLC Column (Waters...
PREPARATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM CONTAINING TERBUTALINE SULPHATE
In this study, investigation of an oral colon specific, pulsatile device to achieve time and/or site specific release of terbutaline sulphate, based on chronopharmaceutical consideration. The basic design consists of an...
PHARMACOGNOSTICAL STUDY OF NEOLAMRCKAIA CADAMBA (ROXB.) BOSSER BARK
The bark of Neolamarckia cadamba (Roxb.) Bosser Family Rubiaceae is reported to have good medicinal values in traditional system of medicines. The present study deals with pharmacognostical examination of morphological a...
REPEATED DOSE 28-DAY ORAL TOXICITY STUDY OF RAW ARECA NUT EXTRACT IN RATS
The aqueous extract of raw areca nut extract was evaluated for the repeated dose 28-day oral toxicity effect on biochemical, haematological, feed consumption, body weight gain and histopathological parameters in rats. In...
A REVIEW ON PULSATILE DRUG DELIVERY SYSTEM
Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient com...