DEVELOPMENT AND VALIDATION OF METHOD FOR DETERMINATION OF CICLESONIDE IN (MICRONIZED) BY HPLC
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 7
Abstract
A simple, selective and rapid reversed phase high performance liquid chromatographic (RPHPLC) method for the analysis of Ciclesonide has been developed and validated. The separation was achieved from HPLC Column (Waters Symmetry C18 5 ยต; 4.6 mm x 250 mm) with a mobile phase consisting of 85 volume of Ethanol with 15 volume of Millie-Q-Water at a flow rate of 1.10 ml/min with UV detection at 242 nm. The method is specific and it is observed that no interference with diluents. The proposed method is accurate with 99.6 % recovery for Ciclesonide and precise (% RSD of area of system precision, % RSD of assay of method precision and Intermediate precision are found to be 0.20 %, 0.20 % and 0.20 % respectively). From the linearity study the correlation coefficient is found to be 0.9999, which indicates that the method is linear over 10 % to 150 % range. The method is found robust for possible changes. Therefore, this method can be used as a more convenient and efficient option for the analysis of Ciclesonide to establish the quality of the drug substance during routine analysis with consistent and reproducible results.
Authors and Affiliations
Momin Mohammad Motalib, Anisuzzaman Md. , Begum Ara, Bellah Faysal, Islam Mostaharul, Parimal Talukder
Keywords
Related Articles
- EP ID EP98739
- DOI 10.7897/2230-8407.04712
- Views 114
- Downloads 0
SOLID LIPID NANOPARTICLES: A PROMISING DRUG DELIVERY SYSTEM
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences....
NEBULIZATION THERAPY - A NOVEL APPROACH TO DRUG DELIVERY SYSTEM IN AYURVEDA
The process of Nebulization involves a suspension of fine vaporized liquid droplets--otherwise known as aerosol--to administer fluids, oxygen and liquid medication directly to the respiratory system. Nebulizers are commo...
CORE KNOWLEDGE OF KEY POLICIES IN DRUG FORMULARY AND INTERVENTIONS FOR PRESCRIBING PRACTICE AMONG MEDICAL OFFICERS AND STUDENTS: SRI LANKAN PERSPECTIVE
Awareness for effective use of drug formulary and prescribing practices for medical practitioners and students is essential to maintain an affordable and sustainable health care system for a country. In this study, knowl...
BIOLOGICAL AND ANTIOXIDANT ACTIVITIES OF SILENE SP.
Silene L. is one of the most recognized and widespread genus of Caryophyllaceae family, with more than 700 species on the earth. It is originated from the Mediterranean Region, and this genus is spread out in mild climat...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF BALANITES AEGYPTIACA LINN. DELILE. STEM BARK
Various pharmacognostical parameters including macroscopy, microscopy, Physiochemical and behavior of powdered drug on treatment with different chemical reagents were studied on the stem bark of Balanites aegyptiaca Linn...