Deadly Combination; Ti̇kagrelor and Abciximab
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 8
Abstract
Introduction: Incremental improvements in pharmacotherapy for percutaneous coronary intervention continue to reduce the incidence of adverse clinical events for the treatment of both stable coronary artery disease and acute coronary syndromes. In addition to anticoagulation with either heparin or bivalirudin, platelet inhibition with dual antiplatelet therapy represented a major advancement in reducing acute and late vessel thrombosis. Case report: Fourty nine years old man admitted to the coronary angiography unit with anterior miyocardial infarction diagnosis. Before the patient underwent coronary angiography, 300 mg acetylsalicylic acid and 180 mg ticagrelor were applied as the drug. The patient's coronary appearance was left descending artery total and intensive thrombus. During the patient's operation, heparin was administered 10,000 units, intracoronary abciximab and thrombus aspiration was applied. Then, stent implanted to LAD osteal lesion. After stent implantation thrombus went to the intermediate artery and multiple balloon dilatation was applied. Timi-1 current provided after iv abciximab treatment then control of coronary angiography planned. However, hemoptysis developed after severe respiratory distress in the patient's appointments. Conclusion: There are not enough randomized clinical trials on the combined use of ticagrelor and glycoprotein IIb / IIIa inhibitor. This fatal complication shows that patients with antiaggregant and anticoagulant medications require much more careful follow-up for bleeding.
Authors and Affiliations
Zafer Yalım, Sümeyra Alan Yalım, Erol Gürsoy
Keywords
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