Deficiency of calcitriol in diabetic retinopathy patients of south Indian population
Journal Title: Medpulse International Journal of Ophthalmology - Year 2018, Vol 7, Issue 2
Abstract
Background: Diabetes mellitus (DM) is a large public health disorder which affects more than 300 million individuals worldwide, with significant morbidity and mortality. The prevalence of Diabetic Retinopathy varies from 20% to 80% in different studies according to previous literature. The increased physical activity is highly associated with less severe levels of Diabetic Retinopathy. serum 25-hydroxyvitamin D (25(OH)D) levels were almost decreased in type 2 diabetic patients with retinopathy when compared with type 2 patients who had no microangiopathy. Objectives The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency. Materials and Methods: This study was conducted from July 2016 to Dec 2016 in Ophthalmology department of ESIC Medical College and Hospital, Sanathnagar, Hyderabad. During the study period, 100 subjects of both the sexes were included in the study after obtaining informed consent; 50 being cases with Diabetic Retinopathy and 50 without Diabetic Retinopathy, using convenient sampling. Exclusion criteria included patients having known risk factors of diabetic retinopathy mainly people who were hypertensive or pregnant and lactating women. The serum of the patients’ samples were assessed by Chemiluminescence immunoassay [CLIA] of serum 25 hydroxy Vitamin D determination at ESIC Medical College and Hospital, Santhnagar, Hyderabad. Retinopathy was assessed using ZEISS VISUCAM 500 fundus camera at ESI Hospital, Nacharam, Hyderabad. Results: The sample included 50 patients with Diabetic Retinopathy and 50 without Diabetic Retinopathy. Mean age of the DR cases was 51.0 ±10.4 years and those without DR were 52.0 ±8.2 years. There were 25 (50%) males in patients with DR while 33 (66%) in patients without DR. The P-value was highly significant between both the groups (p=0.001). Conclusion: There is a statistically significant association between vitamin D deficiency and DR.
Authors and Affiliations
Gannaram Laxmi Prasad, Porika Ram Mohan lal
Keywords
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